abstract soil crust decreases soil infiltration and prevents plant stablishment. thus reduction of crust effects is a prominent way to avert desertification. this study was conducted to investigate the effect of polyacrylamide on emergence of canola seedlings in a crusted soil and some physicochemical properties of soil such as ph, ec, sar and bulk density in a field located in date and tropica...

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical strategy in medicinal chemistry. The general underlying principle is that by maintaining the features of the carboxylic acid critical for biological activity, but appropriately modifying the physicochemical properties, improved analogs may result. In this context, a systematic assessment of the ph...

The concept of drug-likeness helps to optimise pharmacokinetic and pharmaceutical properties, for example, solubility, chemical stability, bioavailability and distribution profile. A number of molecular descriptors have emerged as reasonably informative and predictive, for example, the Rule-of-Five. Here, we review some current approaches, then discuss their major shortcoming, namely the static...