Insulin resistance, hyperglycemia, and type 2 diabetes are among the sequelae of metabolic syndromes that occur in 60-80% of human immunodeficiency virus (HIV)-positive patients treated with HIV-protease inhibitors (PIs). Studies to elucidate the molecular mechanism(s) contributing to these changes, however, have mainly focused on acute, in vitro actions of PIs. Here, we examined the chronic (7...

Potato inhibitor II (Pin-II) proteins are plant serine proteinase inhibitors (PIs) that occur in various plant species. Pin-II PIs are characterized by inhibitory repeat domains (IRDs) which form their functional units and show extensive sequence variation. Various studies have been conducted to gauge the occurrence (spatial and temporal) of Pin-II PIs and their appearance in response to biotic...

HIV disease became a manageable chronic disease since combination antiretroviral therapy (cART) was introduced as the standard treatment regimen. However, the emergence of drug-resistant viruses is a major problem associated with cART. A phenotypic drug susceptibility test using a lentiviral vector was established and applied to evaluate new protease inhibitors (PIs). Lentiviral vectors represe...

The objective of this paper is to present a technique for order preference by similarity to ideal solution (TOPSIS) algorithm to linear fractional bi-level multi-objective decision-making problem. TOPSIS is used to yield most appropriate alternative from a finite set of alternatives based upon simultaneous shortest distance from positive ideal solution (PIS) and furthest distance from negative ...

In this paper, a novel and simple control strategy, based on state feedback method is suggested to control the power injection system (PIS). The considered PIS is composed of, a DC voltage source, a voltage source inverter (VSI) and a L-C-L filter. The DC source includes the battery source with boosted voltage. The battery can be charged with photovoltaic cells. Since, the grid voltage acts as ...

GENERAL PURPOSE To provide information from a review of literature about economic evaluations of preventive strategies for pressure injuries (PIs). TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in this educational ac...

Process intensification strategy (PIS) is emerging as an interesting guideline to revolutionize process industry in terms of improved efficiency and sustainability. Membrane engineering has appeared as a strong candidate to implement PIS. The most significant progress has been observed in desalination where substantial reduction in overall energy demand, environmental footprint, and process haz...

The stage-specific antimalarial activities of a panel of antiretroviral protease inhibitors (PIs), including two nonpeptidic PIs (tipranavir and darunavir), were tested in vitro against Plasmodium falciparum. While darunavir demonstrated limited antimalarial activity (effective concentration [EC(50)], >50 microM), tipranavir was active at clinically relevant concentrations (EC(50), 12 to 21 mic...

In this study, we examine the structures of 10 personality inventories (PIs) widely used for personnel assessment by mapping the scales of PIs to the lexical Big Five circumplex model resulting in a Periodic Table of Personality. Correlations between 273 scales from 10 internationally popular PIs with independent markers of the lexical Big Five are reported, based on data from samples in 2 coun...