The aim of the study was to determine the effect of pituitary transcription factor 1 (POU1F1, Pit1) and the polymorphism of growth hormone releasing hormone (GHRH) genes on selected pig performance traits. The animals used were the progeny of Polish Landrace × Polish Large White crossbred sows and Polish Landrace, Polish Large White, Duroc or Pietrain boars. Eighteen perfor-mance traits were re...

This study was carried out to investigate the association of POU1F1 (POU domain, class 1, transcription factor 1, Pit1, renamed as POU1F1) gene with backfat thickness (mm), carcass weight (kg), pH, and color values (L(*), a(*), b(*)) in crossbred pigs (Landrace x Yorkshire x Duroc). Frequency of the AA genotype indel was at the highest level (66.67%). Frequency of A allele (0.81) was higher tha...

Mutations in Prophet of PIT1 (Prop1), one of several homeodomain transcription factors that are required for the development of the anterior pituitary gland, are the predominant cause of MPHD (multiple pituitary hormone deficiency) in humans. We show that deletion of Prop1 in mice causes severe pituitary hypoplasia with failure of the entire Pit1 lineage and delayed gonadotrope development. The...

The mechanisms by which transient gradients of signaling molecules lead to emergence of specific cell types remain a central question in mammalian organogenesis. Here, we demonstrate that the appearance of four ventral pituitary cell types is mediated via the reciprocal interactions of two transcription factors, Pit1 and GATA2, which are epistatic to the remainder of the cell type-specific tran...

Prophet of POU1F1 (PROP1) plays direct or indirect important roles in the morphogenesis of pituitary gonadotropes as well as lactotropes, somatotropes and caudomedial thyrotropes. It also controls the expression of growth hormone, prolactin and thyrotropin subunits through regulatory PIT1 factor. These hormones have important influences on production traits in most animal species including the ...

A non-motile, rod-shaped and aerobic marine bacterium, designated strain KYW314(T), was isolated from seawater collected from the South Sea, Republic of Korea. Cells were Gram-negative, catalase- and oxidase-positive and had proteolytic activity. The major fatty acids were iso-C(15 : 0) (17.2 %), C(16 : 0) (11.1 %), iso-C(17 : 0) (10.5 %) and C(18 : 1)ω 7c (10.0 %). The DNA G+C content was 56.4...

While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of beta-catenin remains a major challenge. Here, we report an unexpected strategy for beta-catenin-dependent regulation of cell-lineage determinat...