Abstract Sepsis and autoimmune diseases remain major causes of morbidity mortality. The last decade has seen a new appreciation platelets in host defense, both immunity thrombosis. Platelets are first responders the blood to microbes or non?microbial antigens. role physiologic is counterbalanced by their pathology, for example, microvascular encounter antigens via innate adaptive immun...

Platelets play a role in tumor angiogenesis and growth and are the main transporters of several angiogenesis regulators. Here, we aimed to determine the levels of angiogenesis regulators and epithelial-mesenchymal transition factors sequestered by circulating platelets in breast cancer patients and age-matched healthy controls. Platelet pellets (PP) and platelet-poor plasma (PPP) were collected...

Glu-plasminogen, the native form of plasminogen, interacts in a specific and saturable manner with unstimulated human platelets, and the binding is enhanced fivefold by thrombin stimulation (Miles and Plow, 1985. J. Biol. Chem. 260:4303). This study characterizes the nature of the Glu-plasminogen binding sites by analyzing platelets deficient in selected proteins and functions. Platelets from p...

in the present study, the effect of various weight fractions of graphene nanoplatelet (gpl) on flexural fatigue behavior of epoxy polymer has been investigated at room temperature and generally the temperature was monitored on the surface of specimen during each test. the flexural stiffness of grapheme nano-platelet/epoxy nanocomposites at 0.1, 0.25 and 0.5 wt. % as a main effective parameter o...

Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet. The aim of this study was to develop a model enabling the quantitative analysis of platelet kinetics and platelet-endothelium interaction within consecutive segments of the pulmonary microcirculation...

Prothrombinase complex assembly, in real time, on platelets adherent to immobilized von Willebrand Factor (vWf) was examined by total internal reflection fluorescence spectroscopy (TIRFS). Electron microscopy showed that the platelets adhered to vWf in a largely unactivated state and could be activated by thrombin. Antibody binding to glycoprotein (GP) Ib and functional GPIIb-IIIa receptor mole...