Although examples of nickel(ii), palladium(ii) and platinum(ii) N-heterocyclic tetracarbene complexes are known in the literature, particularly platinum(ii) tetracarbene complexes are rare. We developed a new synthetic route via biscarbene acetate complexes, which make homoleptic as well as heteroleptic platinum(ii) tetracarbene complexes accessible. The reported photoluminescence data show tha...

OBJECTIVE To develop, validate, and apply a method for the determination of platinum contamination, originating from cisplatinum, oxaliplatinum, and carboplatinum. METHODS Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine platinum in wipe samples. The sampling procedure and the analytical conditions were optimised and the assay was validated. The method was applied t...

Platinum-resistance is the most crucial problem for treatment of ovarian cancer. There is a clinical need for new treatment strategies which overcome platinum resistance. As survival is strongly influenced by immunological parameters, immunotherapeutic strategies appear promising. Therefore a better understanding of the interaction between ovarian tumour cells and cells of the immune system is ...

Platinum-based chemotherapeutics are amongst the most powerful anti-cancer drugs. Although their exact mechanism of action is not well understood, it is thought to be mediated through covalent DNA binding. We investigated the effect of platinum-based chemotherapeutics on signaling through signal transducer and activator of transcription (STAT) proteins, which are involved in many oncogenic sign...

Severalcis-platinum coordination complexesweretested for their carcinogenic and mutagenic potencies in view of the known electrophilic reactivities of antitumor platinum complexes toward cellular nucleophiles and the mutagen icities of some of these complexes. cis-Dichlorodiammineplatinum(Il) (total dose, 32.5 mg/kg) administered i.p. over 10 to 19 weeks increased the lung adenoma multiplicity ...

bio-directed synthesis of nanoparticles is an interesting field of rapid advancement for biologists,chemists and materials scientists, especially in light of efforts to find out green methods of inorganicmaterial synthesis. in the present study, green synthesis of platinum nanoparticles (ptnps) using sheepmilk is reported for the first time. by adjusting the concentrations of chloroplatinic aci...

the series of mono-metallic and bi-metallic catalysts have been prepared by impregnatingwith solutions containing compound of h2ptc15,nbc15 and lml hc1 (0.1 mol). the activityand selectivity of the catalysts have been determined under conditions at 450-500°c, 15-30atm. molar ratio h2/c7h16=5 and vvh=1.5/h for converting n-heptane. under theseexperimental conditions it has been established that ...

Electrodeposition of platinum and silver into hydrophobic and hydrophilic microporous silicon layers was investigated using chemically-modified microporous silicon electrodes. Hydrophobic microporous silicon enhanced the electrodeposition of platinum in the porous layer. Meanwhile hydrophilic one showed that platinum was hardly deposited within the porous layer and a filmy growth of platinum on...