Platinum is ubiquitous in the production sectors of chemicals and fuels; however, its scarcity in nature and high price will limit future proliferation of platinum-catalysed reactions. One promising approach to conserve platinum involves understanding the smallest number of platinum atoms needed to catalyse a reaction, then designing catalysts with the minimal platinum ensembles. Here we design...

Acquisition of platinum resistance following first line platinum/taxane therapy is commonly observed in ovarian cancer patients and prevents clinical effectiveness. There are few options to prevent platinum resistance; however, demethylating agents have been shown to resensitize patients to platinum therapy thereby demonstrating that DNA methylation is a critical contributor to the development ...

in this study, polystyrene ethylene butylene polystyrene (psebs) was functionalized to prepare mono and bipolar ion exchange membranes. in the case of the bipolar membrane, platinum was used as the intermediate layer. nacl solution of concentration ranging from 5 g/l to 25 g/l was used as the feed solution. a commercially procured ion exchange membrane made of polystyrene divinyl benzene was al...

Background and Aim: Preparation of root canal with rotary nickel-titanium (NiTi) instruments may potentially create microcracks that can lead to vertical root fracture. This study aimed to compare the incidence of crack formation by BioRaCe and Edge Taper Platinum systems in the mesiobuccal canals of extracted first mandibular molars. Materials and Methods: In this experimental study, 50 first...

The cathodic dissolution of platinum, resulting from the oxygen reduction reaction (ORR) or hydrogen peroxide reduction on platinum, has been investigated. Highly oxidizing hydroxyl radicals (OH•) are believed to be the species responsible for the platinum dissolution phenomenon. These radicals are produced from the ORR byproduct, hydrogen peroxide, through a 1 electron reduction pathway (H2O2 ...

Although ovarian carcinomas with mutated BRCA1 or BRCA2 are sensitive to platinum compounds, such carcinomas eventually develop platinum resistance. Previously, we showed that acquired resistance to cisplatin in BRCA2-mutated tumors can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. Here, we show that secondary mutations of BRCA1 also occu...

The electrocatalysts utilized as the prospective electrodes in fuel cells and high efficient energy conversion devices require both the interconnected channels for efficient electrolyte transportation and the superior catalytic activity with long service life. In this work, nanoporous gold with the rigid skeletons in three dimensions is partially decorated by porous platinum shell containing na...

Platinum-based catalysts have been considered the most effective electrocatalysts for the hydrogen evolution reaction in water splitting. However, platinum utilization in these electrocatalysts is extremely low, as the active sites are only located on the surface of the catalyst particles. Downsizing catalyst nanoparticles to single atoms is highly desirable to maximize their efficiency by util...

c/s-Diammine-1,1-cyclobutane dicarboxylate platinum(ll) (CBDCA, JM8) is a nonnephrotoxic analogue of cisplatin cur rently undergoing clinical evaluation. Pharmacokinetic studies have been performed in patients receiving CBDCA (20 to 520 mg/sq m) as a 1-hr infusion without hydration or diuresis. Follow ing the end of the infusion, plasma levels of total platinum and ultrafilterable (M, < 50,000)...

Platinum bis-amidine complexes (both the cis and trans isomers) are stable in acetone and chlorinated solvents but are unstable in protic solvents such as methanol or water. In the latter solvents an initial cis/trans isomerization leads to formation of an equilibrium mixture with a cis/trans ratio of about 1:4; subsequently a dinuclear platinum(III) complex (1) is formed under aerobic conditio...