Platinum-based chemoradiotherapy (CRT) is a standard front-line treatment for locally advanced non-small cell lung cancer (NSCLC). However, no clinical trials have compared the efficacy and toxicity of platinum combination and docetaxel as subsequent re-challenge chemotherapies after cancer recurrence following CRT. This study aimed to evaluate the efficacy and toxicity of platinum combination ...

Three murine leukemia lines resistant to cÃo-diamminedichloroplatinum(II) and one line resistant to diaminocyclohexane (DACH) platinum(II) complexes were compared to their platinum-sensitive parent lines to determine whether differences in net platinum accumulation were related to the resistant phenotype. The ciVdiamminedichloroplatinum(II}-resistant lines (L1210PIR4, L1210DDPS, P388PtR4) and t...

The objectives of this study were to assess the pharmacokinetics and safety of subcutaneously delivered carboplatin in poloxamer 407 in rats. Carboplatin (5mg/rat) in 0.5ml poloxamer 407 (1.0 ml total volume) was administered subcutaneously in a right subcutaneous perineal incision in all 12 treatment rats. Three control rats received 1.0 ml of poloxamer 407. Total platinum was measured in plas...

Reactions of Complexes of Platinum Metals with Bio-Molecules Water Soluble Rhodium Catalysts The Destruction of Polychlorinated Biphenyls Chemical Conversion of Carbon Dioxide The Electrodeposition of Platinum and Platinum Alloys Ruthenium in Cancer Chemotherapy Lean-Burn Oxygen Sensor Material Control of Corrosion in Molten Carbonate Fuel Cells Flammable Gas Detection International Congress on...

Forty microampere current was generated on a platinum-titanium dioxide Schottky diode during the platinum catalyzed steady-state oxidation of carbon monoxide at 80 degrees C. For reaction events that produced four CO(2) molecules, three injected electrons were collected in a diode comprising a 5 nm thick platinum and a 150 nm titanium dioxide film. The electron injection flux depends on the thi...

Single-crystal (SX) nickel aluminide alloys have potential for structural applications where hightemperature strength and oxidation resistance are required. In this work, SX deposits of the Ni3Albased IC221W alloy were produced on a SX Ni-base superalloy substrate by means of the laser-engineered net shaping (LENS) process. The microstructure of the deposits was characterized. The effects of pr...

Platinum-based chemotherapy, such as cisplatin, oxaliplatin, and carboplatin, is one of the most widely utilized classes of cancer therapeutics. While highly effective, the clinical applications of platinum-based drugs are limited by their toxicity profiles as well as suboptimal pharmacokinetic properties. Therefore, one of the key research areas in oncology has been to develop novel platinum a...

Results of analysis for platinum in 97 autopsy sets are presented. Analysis was performed by a specially developed emission spectrochemical method. Almost half of the individuals studied were found to have detectable platinum in one or more tissue samples. Platinum was found to be deposited in 13 of 21 tissue types investigated. Surprisingly high values were observed in subcutaneous fat, previo...

The transport system of platinum-based anticancer agents is crucial for drug sensitivity. Increasing evidence indicates that the copper transport system is also involved in the cellular influx and efflux of platinum drugs. The copper chaperone Atox1 has been shown to bind to cisplatin in vitro and in cells. Previous results reveal that copper binding promotes the reaction between Atox1 and cisp...