Abstract Study question What is the frequency of PLCZ1, ACTL7A and ACTL9 variants in male patients suffering from fertilization failure (FF) after ICSI? Summary answer Male with FF ICSI exhibit PLCZ1 (27,3%), (13,6%) (4,5%). Some present combined ACTL7A/ACTL9 variants. known already has been often attributed to phospholipase C zeta (PLCζ) deficiency, consequently insufficient calcium release, n...

Abstract Study question Given that Actrt1 knockout induces teratospermia, fertilization failure and severe male infertility in mice, will ACTRT1 deficiency affect sperm morphology fertility humans? Summary answer The ∼110 kb microdeletion of X chromosome only including gene was identified inducing head deformation an infertile Chinese man. What is known already actin-related proteins, ACTRT1, A...

Low and/or total failed fertilization following ICSI is a disappointing effect that some couples may face during their treatment which may have severe social and economic consequences for these infertile couples. This phenomenon has been mainly attributed to failed oocyte activation post ICSI. Researchers have regarded this failure due to the absence or deficiency of sperm associated to oocyte ...