OBJECTIVE Lipodystrophies are categorized by the extent of fat loss (generalized vs. partial) and by inheritance (congenital vs. acquired). We examined whether a group of patients with partial lipodystrophy of the limbs (PLL), type 2 diabetes mellitus (T2DM), and an absence of a family history of lipodystrophy constitute a new clinical subtype. RESEARCH DESIGN AND METHODS Ten women with T2DM ...

A phase-locked loop (PLL) and delay-locked loop (DLL) design with adaptively adjusting bandwidth enables optimal performance over a wide frequency range and across process, voltage, and temperature variations. A design methodology of such adaptive-bandwidth PLLs and DLLs is described. To assess the impact of each circuit parameter directly, we derive a discrete-time, open-loop dynamic model of ...

A polyethylene glycol-poly(ε-benzyloxycarbonyl-l-lysine) (PEG-SS-PLL) block copolymer based on a disulfide-linked, novel biodegradable catiomer bearing a PEG-sheddable shell was developed to avoid "PEG dilemma" in nanoparticle intracellular tracking of PEG-PLL where PEG was nondegradable. However, PEG-SS-PLL catiomers have not been used to deliver small interfering VEGF RNA (siVEGF) in antiangi...

A fully integrated digitally controlled PLL used as a clock multiplying circuit is designed and fabricated. The PLL has no off-chip components and it is made from standard cells found in most digital standard cell libraries. It is therefore portable between processes as an IP-block. Using a 0.35 μm standard CMOS process and a 3.0 V supply, the PLL has a frequency range of 152 MHz to 366 MHz and...

Engineered polymer films are of significant importance in the field of biomedicine. Poly(dopamine) (PDA) is becoming more and more a key player in this context. Herein, we deposited mixed films consisting of PDA and poly(L-lysine) (PLL) of different molecular weights. The coatings were characterized by quartz crystal microbalance with dissipation monitoring, atomic force microscopy, and X-ray p...

A amphiphilic block copolymer composed of conventional monomethoxy (polyethylene glycol)-poly (d,l-lactide-co-glycolide)-poly (l-lysine) (mPEG-PLGA-b-PLL) was synthesized. The chemical structure of this copolymer and its precursors was confirmed by Fourier Transform Infrared Spectroscopy (FTIR), (1)H Nuclear Magnetic Resonance ((1)H NMR) and Gel Permeation Chromatography (GPC). The copolymer wa...

OBJECTIVE(S) Microarrays are potential analyzing tools for genomics and proteomics researches, which is in needed of suitable substrate for coating and also hybridization of biomolecules. MATERIALS AND METHODS In this research, a thin film of oxidized agarose was prepared on the glass slides which previously coated with poly-L-lysine (PLL). Some of the aldehyde groups of the activated agarose...

A new modification method for glass slides was developed and applied to make ThinPrep Pap smears, in order to increase the adhesion ability of cervical exfoliative cells. 3-glycidyloxypropyl trimethoxysilane (GOPS) was coated on the glass slides firstly on the slides, then poly-L-lysine (PLL) was covalently modified onto the above epoxy-terminated slides to form GOPS-PLL double decorated slides...

This data article presents data associated with the research article entitled "Evaluation of cell-laden polyelectrolyte hydrogels incorporating poly(L-lysine) for applications in cartilage tissue engineering" (Lam et al., 2016) [1]. Synthetic hydrogel composites fabricated using oligo(poly(ethylene glycol) fumarate) (OPF) macromers were utilized as vehicles for the incorporation of poly(L-lysin...

--The All-Digital Phase-Locked Loop (ADPLL) is digital electronic circuit that are used in modern electronic communication systems like frequency synthesizer, modulator/demodulator etc. This paper presents a review of various ADPLL techniques. The range of input frequency of ADPLL is 40 to 98 MHz; the output frequency may be up to 2.92 to 4 GHz range. The components of ADPLL such as phase detec...