The demand for "green" degradable composite materials increases with growing environmental awareness. The key challenge is achieving the preferred physical properties and maintaining their eco-attributes in terms of the degradability of the matrix and the filler. Herein, we have designed a series of "green" homocomposites materials based purely on polylactide (PLA) polymers with different struc...

Background: The innovative repair materials for the bones are still lacking. So, we synthesized a porous microsphere by using basic fibroblast growth factor (bFGF), polylactide-co-glycolide (PLGA), poly L-lactic acid (PLLA) and hydroxylapatite (HAP), and its biocompatibility with bone marrow mesenchymal stem cells (BM-MSCs) was investigated in vitro. Methods: A modified solvent extraction/evapo...

OBJECTIVES When poly-L-lactic acid (PLLA) was first introduced (marketed as New-Fill), incorrect injection technique was largely responsible for the manifestation of device-related adverse events in the form of subcutaneous papules and areas of induration. Now marketed as Sculptra, widespread clinical experience with injectable PLLA has resulted in a wealth of information on product reconstitut...

Medical-profession-accepted and the US Food and Drug Administration (FDA)-approved biodegradable polymers have been used for tissue engineering applications over the last two decades due to their good biocompatibility and acceptable biodegradation properties. Poly(L-lactide) (PLLA) is a linear aliphatic biodegradable polymer and has been widely studied for use as a scaffolding material for huma...

abstract due to their mulitpotency, mesenchymal stem cells (mscs), have the ability to proliferate and differentiate into multiple mesodermal tissues. the aim of this study was to isolate mscs from human umbilical cord (hucmscs) to determine their osteogenic potential on nanofibrous scaffolds. to this end, poly (l-lactic acid) (plla)/nano hydroxyapatite (ha) composite nanofibrous scaffolds were...

Colon cancer is one of the major causes of death in the Western world. Early detection significantly improves long-term survival for patients with colon cancer. Near-infrared (NIR) fluorescent nanoparticles are promising candidates for use as contrast agents for tumor detection. Using NIR offers several advantages for bioimaging compared with fluorescence in the visible spectrum: lower autofluo...

Poly(L-lactide) (PLLA) oligo-esters with α-hydroxyl-ω-alkyl (alkyl = −CH2−[CH2−CH2]n−CH3, where n = 1, 2, 4, 5, 6, 7, 8, 9, and 10) end groups were synthesized by ring-opening polymerization of L-lactide (L-LA) catalyzed by tin(II) 2ethylhexanoate Sn(Oct)2 in the presence of aliphatic alcohols as initiators (HO−CH2−[CH2−CH2]m−CH3, where m = 1, 2, 4, 5, 6, 7, 8, 9, and 10). High yields (∼ 62 to ...

Abstract For the in vitro examination of effects on cells and tissues metal ions derived from implants by wear corrosion, a system is needed to release controlled sustained manner. As small concentrations may have an impact biological systems, corresponding slow over defined period time necessary. Here, manufacturing method polymeric Poly(L-lactic acid) (PLLA) films with incorporated cobalt via...

INTRODUCTION A 3D-nanofiber scaffold acts in a similar way to the extracellular matrix (ECM)/basement membrane that enhances the proliferation and self-renewal of stem cells. The goal of the present study was to investigate the effects of a poly L-lactic acid (PLLA) nanofiber scaffold on frozen-thawed neonate mouse spermatogonial stem cells (SSCs) and testis tissues. METHODS The isolated sper...

Introduction. Tissue engineering is a new methodology for addressing meniscal injury or loss. Synovium may be an ideal source of cells for in vitro meniscal fibrocartilage formation, however, favorable in vitro culture conditions for synovium must be established in order to achieve this goal. The objective of this study was to determine cellularity, cell distribution, and extracellular matrix (...