PURPOSE To compare rates of topographic change in ocular hypertensive eyes that develop primary open-angle glaucoma (POAG) compared to eyes that do not, and to identify factors that influence the rate of change. DESIGN Longitudinal, randomized clinical trial. METHODS Four hundred forty-one participants (832 eyes) in the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hy...

PURPOSE Glaucoma is a complex neurodegenerative disorder of the eye. Primary Open Angle Glaucoma (POAG) is the most common type, accounting for over half of the total cases. Recently, a significant difference in the distribution of the codon 72 polymorphism of the tumor suppressor gene p53 between control subjects and POAG patients of Chinese origin (p=0.00782) was demonstrated. The proline res...

PURPOSE To test the genetic association between Japanese patients with primary open-angle glaucoma (POAG) and the previously reported POAG susceptibility loci and to perform genotype-phenotype analysis. METHODS Genetic associations for 27 SNPs from 16 loci previously linked to POAG were assessed using genome-wide SNP data of the primary cohort (565 Japanese POAG patients and 1,104 controls). ...

purpose : to investigate the association of primary open angle glaucoma (poag) and systemic hypertension in patients referred to farabi eye hospital methods : in this case-control study in farabi eye hospital. one hundred patients were selected randomly from poag patients of glaucoma clinic, farabi eye hospital. control group consists of 100 patients, candidates for cataract surgery. history of...

Purpose Assessment and a direct comparison of retinal vessel density with the thickness inner layer (IRL) outer (ORL) in same regions macula subjects Alzheimer’s disease (AD) primary open-angle glaucoma (POAG). Methods We analyzed data from 48 eyes healthy control (HC) participants, 71 POAG, 49 AD patients. Ophthalmic examination included optical coherence tomography (OCT) imaging to measure IR...

Introduction/Objective. Primary open-angle glaucoma (POAG) treatment should be individually tailored to the disease severity and type, effectiveness secondary side effects of medications used. This research aimed assess direct medical costs cost associated with pharmacotherapy in visually impaired people POAG according severity. Methods. scientific study is designed as an observational cross-se...

PURPOSE To determine whether the photopic negative response (PhNR) of the electroretinogram (ERG) is reduced in patients with primary open angle glaucoma (POAG). METHODS ERGs were recorded with DTL electrodes from 62 normal subjects (16 to 82 years), 18 POAG patients (47 to 83 years) and 7 POAG suspects (46 to 73 years) to brief flashes (<6 ms), and also in a few subjects to long (200 ms) red...

PURPOSE Neurotrophin-4 protein (NT-4) plays a role in the protection of retinal ganglion cells by activating tyrosine kinase B (TrkB) receptors. A recent study identified mutations within the neurotrophin-4 (NTF4) gene to account for 1.7% of primary open-angle glaucoma (POAG) in Europeans. The aim of this study was to investigate the frequency of NTF4 mutations in Chinese POAG patients. METHO...

Purpose To identify microRNAs (miRNAs) involved in primary open-angle glaucoma (POAG), using genetic data. MiRNAs are small noncoding RNAs that posttranscriptionally regulate gene expression. Genetic variants in miRNAs or miRNA-binding sites within gene 3'-untranslated regions (3'UTRs) are expected to affect miRNA function and contribute to disease risk. Methods Data from the recent genome-wi...

PURPOSE Tumor necrosis factor-α (TNF-α), an important proinflammatory cytokine, exerts a variety of physiologic and pathogenic effects that lead to tissue destruction. Recent laboratory evidence indicates that TNF-α have either protective or adverse effects on primary open angle glaucoma (POAG). Inheritance of the TNF-α (-863) C allele has been associated with an elevated risk of Alzheimer dise...