background: glaucomatous neuropathy is a type of cell death due to apoptosis. the p53 gene is one of the regulatory genes of apoptosis. recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (poag) has been studied in some ethnic groups. this study is the first association analysis of poag and p53 codon 72 polymorphism in iranian patients...

In India, mutations in Cytochrome P450 (CYP1B1) are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited in this study. Genomic DNA was is...

there are reports from different countries that some types of glaucoma are associated with blood groups. this cross-sectional study was performed on 400 glaucomatous patients [100 patients in each group of primary open angle glaucoma (poag), chronic angle closure glaucoma (cacg), pseudoexfoliative glaucoma (pexg) and primary congenital glaucoma (pcg)] and 400 blood donors as control group to as...

Background: Glaucomatous neuropathy is a type of cell death due to apoptosis. The p53 gene is one of the regulatory genes of apoptosis. Recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (POAG) has been studied in some ethnic groups. This study is the first association analysis of POAG and p53 codon 72 polymorphism in Iranian patients...

objective: to compare the frequency of helicobacter pylori (h. pylori) infection in subjects with primary open angle glaucoma (poag) vs controls. methods: in a case-control study, 44 patients with primary open angle glaucoma and 79 patients with senile cataract (control group) were investigated for serum level of anti-h. pylori antibody using the enzyme-linked immunosorbant assay (elisa) method...

purpose : to compare the serum homocysteine (hcy) level in healthy control individuals and in patient with primary open angle glaucoma (poag) and pseudoexfoliative glaucoma (pexg) methods : in this cross sectional study, 79 subjects including 36 patients with pexg, 23 patients with poag, and 20 matched healthy control individuals were recruited. those who used alcohol and mediations affecting h...

results we identified no mutations in these patients in the three screened positions. conclusions to ensure that these genes play no role in the disease, evaluation of the non-coding regions of both the cyp1b1 and myoc genes is strongly recommended, since other genes are involved in the pathogenesis of glaucoma. patients and methods forty patients with poag were recruited from the ophthalmic di...

A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data pro...