Premature ovarian insufficiency (POI) occurs in 1% of reproductive-age women. The ovarian manifestation ranges from the presence of a variable population of follicles (follicular) to the absence of follicles (afollicular), and in the majority of cases the cause is unknown. A transgenic mouse model of follicular POI, the Double Mutant (DM), arises from oocyte-specific deletion of Mgat1 and C1gal...

Primary ovarian insufficiency (POI) affects about 1% of women in the reproductive age. These women are below 40 years of age, experience amenorrhoea for at least 4 months, and have two readings of serum follicular stimulating hormone (FSH) of more than 40IU/L at one month apart [1-3]. Those who plan to expand their families are mostly left with the option of adoption or oocyte donation. However...

Point-of-Interest (POI) data are location enriched word data, which consist of personal names, place names including administrative districts, and names of business and recreational locations. They are essential to the development of applications such as Telematics, wireless location-based services (LBS), and tourism and other business applications. Being a major component of Text-to-Speech (TT...

The rapid urban expansion has greatly extended the physical boundary of our living area, along with a large number of POIs (points of interest) being developed. A POI is a specific location (e.g., hotel, restaurant, theater, mall) that a user may find useful or interesting. When exploring the city and neighborhood, the increasing number of POIs could enrich people’s daily life, providing them w...

This guidance document by the British Menopause Society provides recommendations on the assessment and management of women with premature ovarian insufficiency (POI). The consequences of POI are related to the decline in ovarian function and estrogen deficiency associated with the condition. These can be short-term menopausal symptoms and long-term effects on bone and cardiovascular health, cog...

INTRODUCTION Intestinal manipulation (IM) during abdominal surgery results in intestinal inflammation leading to hypomotility or ileus. Mast cell activation is thought to play a crucial role in the pathophysiology of postoperative ileus (POI). However, this conclusion was mainly drawn using mast cell-deficient mouse models with abnormal Kit signaling. These mice also lack interstitial cells of ...

The revolution of World Wide Web (WWW) and smart-phone technologies have been the key-factor behind remarkable success of social networks. With the ease of availability of check-in data, the location-based social networks (LBSN) (e.g., Facebook, etc.) have been heavily explored in the past decade for Point-of-Interest (POI) recommendation. Though many POI recommenders have been defined, most of...

The rapid urban expansion has greatly extended the physical boundary of our living area, along with a large number of POIs (points of interest) being developed. A POI is a specific location (e.g., hotel, restaurant, theater, mall) that a user may find useful or interesting. When exploring the city and neighborhood, the increasing number of POIs could enrich people’s daily life, providing them w...

BACKGROUND Increasing age and post-menopausal status are associated with decreasing androgen concentrations in females. Women with premature loss of ovarian function, such as primary ovarian insufficiency (POI) or iatrogenic menopause may be at increased risk for diminished testosterone levels at a relatively young age. Differentiation between a hypoandrogenic or normoandrogenic state in women ...