Tour recommendation and itinerary planning are challenging tasks for tourists, due to their need to select Points of Interest (POI) to visit in unfamiliar cities, and to select POIs that align with their interest preferences and trip constraints. We propose an algorithm called PERSTOUR for recommending personalized tours using POI popularity and user interest preferences, which are automaticall...

Early menopause or premature ovarian insufficiency (POI) is a common cause of infertility in women and affects about one per cent of young women. This disorder has significant psychological sequelae and major health implications. Its relevance has increased in recent years due to the fact that age of motherhood is being delayed in developed countries, with the risk of having either primary ovar...

BACKGROUND Estrogens are important factors in the female reproductive functions and are processed by a number of enzymes along their metabolic pathway. The COMT gene constitutes a crucial element in estrogen metabolism and is assumed to be involved in the development of Premature Ovarian Insufficiency (POI). This study aimed to determine whether the presence of the COMT Val/Met polymorphism (rs...

Primary ovarian insufficiency (POI) and polycystic ovarian syndrome are ovarian diseases causing infertility. Although there is no effective treatment for POI, therapies for polycystic ovarian syndrome include ovarian wedge resection or laser drilling to induce follicle growth. Underlying mechanisms for these disruptive procedures are unclear. Here, we explored the role of the conserved Hippo s...

This paper concerns versioning services over Semantic Web (SW) repositories. We propose a novel storage index (based on partial orders), called POI, that exploits the fact that RDF Knowledge Bases (KBs) (a) have not a unique serialization (as it happens with texts) and (b) their versions are usually related by containment (⊆). We discuss the benefits and drawbacks of this approach in terms of s...

INTRODUCTION While we recognise that the term premature menopause is more accepted by most non-specialist health care providers and by the general population, 'primary ovarian insufficiency' (POI) is currently considered the most apposite term to explain the loss of ovarian function, because it better explains the variability of the clinical picture, does not specify definitive failure, and hig...

In the context of geographic information systems (GIS), points of interest (POIs) are descriptions that denote geographical locations which might be of interest for some user purposes. Examples are public transport facilities, historical buildings, hotels and restaurants, recreation areas, hospitals etc. Because information gathering with respect to POIs is usually resource consuming, the user ...

STUDY QUESTION Can high-resolution array comparative genomic hybridization (CGH) analysis of DNA samples from women with primary ovarian insufficiency (POI) improve the diagnosis of the condition and identify novel candidate genes for POI? SUMMARY ANSWER A mutation affecting the regulatory region of growth differentiation factor 9 (GDF9) was identified for the first time together with several...

Merritt and Blikslager (2008) present an excellent challenge to re-examine attitudes towards definition and diagnosis of post operative ileus (POI) in horses. An intriguing aspect of this complex disease is that diagnosis is made largely on the basis of reflux through a nasogastric tube. This is tantamount to diagnosing navicular disease on the observation of a forelimb lameness or pneumonia be...

OBJECTIVES To assess the incidence and economic impact of postoperative ileus (POI) following laparotomy (open) and laparoscopic procedures for colectomies and cholecystectomies in patients receiving postoperative pain management with opioids. METHODS Using the Premier research database, we retrospectively identified adult inpatients discharged between 2008 and 2010 receiving postsurgical opi...