PURPOSE OF REVIEW Despite an incidence of 1% among women under the age of 40, primary ovarian insufficiency (POI) is still poorly understood. As the variable cause and presentation of POI complicate its management, a standard regimen for treatment remains to be established. However, emerging research has provided new insight on current mainstays of treatment as well as novel management approach...

BACKGROUND Ovarian follicular activity in serial hormone profiles has been reported in up to 86% of patients with primary ovarian insufficiency (POI). In most of these studies, patients had a short duration of amenorrhea or irregular menstrual cycles which could influence the occurrence of spontaneous follicular activity. The aim was to study the incidence of follicular activity in serial hormo...

The wide spread of location-based social networks brings about a huge volume of user check-in data, which facilitates the recommendation of points of interest (POIs). Recent advances on distributed representation shed light on learning low dimensional dense vectors to alleviate the data sparsity problem. Current studies on representation learning for POI recommendation embed both users and POIs...

Context The etiology of primary ovarian insufficiency (POI) remains unknown in most cases. Objective We sought to identify the genes causing POI. Design The study was a familial genetic study. Setting The study was performed at two academic institutions. Patients We identified a consanguineous Yemeni family in which four daughters had POI. A brother had azoospermia. Intervention DNA w...

BACKGROUND R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient female mice become infertile around 4 months of age mimicking primary ovarian insufficiency (POI). The study aimed to investigate the reg...

Point of Interests (POI) identification using social media data (e.g. Flickr, Microblog) is one of the most popular research topics in recent years. However, there exist large amounts of noises (POI irrelevant data) in such crowd-contributed collections. Traditional solutions to this problem is to set a global density threshold and remove the data point as noise if its density is lower than the...

Point-of-interest (POI) recommendation becomes a valuable service in location-based social networks. Based on the norm that similar users are likely to have similar preference of POIs, the current recommendation techniques mainly focus on users’ preference to provide accurate recommendation results. This tends to generate a list of homogeneous POIs that are clustered into a narrow band of locat...

Postoperative ileus (POI) after abdominal surgery significantly lowers the life quality of patients and increase hospital costs. However, few treatment strategies have successfully shortened the duration of POI. Electroacupuncture (EA) is a modern way of administering acupuncture and widely used in various gastrointestinal (GI) diseases in the world. Here, we studied the effect of EA on POI and...

Günümüzde web üzerinde kullanıcılar tarafından üretilen konumsal verinin miktarı her geçen gün büyük bir hızla artmaktadır. Bu da, özellikle uygulamaların geliştirilmesi için üzerindeki verileri önemli bilgi kaynağı haline getirmektedir. Özellikle açık veri politikası ile birlikte kitle kaynak girişimlerinin yaygınlaşması ve başarısı, üreticisi kurum kuruluşların toplamada kaynaklı coğrafi bilg...