BACKGROUND Primary ovarian insufficiency (POI) is characterized by 4 to 6 months of amenorrhea and elevated serum FSH and LH in females less than 40 years. Ovarian insufficiency is uncommon in pediatrics and typically results from a chromosomal abnormality or treatment for malignancy. Idiopathic POI in which no apparent precipitant is identified is even rarer. After encountering three teens wit...

The development of mobile social media networks has changed our daily life. More and more people tend to share their locations, emotions and activities with their friends, which are called ‘check-in records’. These geo-tagged data create an unprecedented opportunity for researchers to reveal spatio-temporal activity patterns of citizens [1,2], capture usages of urban public facilities [3], and ...

The Personal Orientation Inventory (POI) profile of Maharishi International University (MIU) students who practiced the Transcendental Meditation technique regularly was compared to profiles presented in the POI manual for a group of college students and for a group of relatively self-actualized people. MIU students scored significantly higher than nonmeditating college students on eight of the...

While developing a web-based travel planning system, the necessity to implement a mobile component has been identified. Such a conception is aimed at a comprehensive support of a workflow that enables users to plan a trip in advance using the web-based application, but to modify the original plan wherever and whenever they want while carrying out the journey. Within both components, POI (Point-...

Ovarian dysfunction before the age of 40 years, characterized by hypergonadotropic hypogonadism and presenting with either primary or secondary amenorrhea, is called primary ovarian insufficiency (POI). POI has a significant genetic component, but the specific genetic cause is often unknown. A novel candidate gene for POI, PSMC3IP, has recently been identified. The aim of this study was to inve...

POI recommendation provides users personalized location recommendation. It helps users to explore new locations and filter uninteresting places that do not match with their interests. Multiple factors influence users to choose a POI, such as user’s categorical preferences, temporal activities and location preferences as well as popularity of a POI. In this work, we define a unified framework th...

STUDY QUESTION Could anti-Müllerian hormone (AMH) mutations be implicated in the development of idiopathic premature ovarian insufficiency (POI)? SUMMARY ANSWER Three rare or unknown missense variants of the AMH gene were identified in a cohort of 55 POI patients; all three variants showed a drastically reduced in vitro bioactivity. WHAT IS KNOWN ALREADY Genetic factors are implicated in 5-...

INTRODUCTION Intestinal inflammatory responses play a critical role in the pathogenesis of postoperative ileus (POI). As cannabinoid receptor-1 (CB1) is involved in inhibiting gastrointestinal (GI) motility and anti-inflammation, we aimed to explore its contribution to POI. METHODS Experimental POI was induced in adult female CB1-deficient (CB1-/-) mice and wild-type littermates (C57BL/6N) by...

1. Postoperative ileus (POI) is an abnormal pattern of gastrointestinal motility characterized by nausea, vomiting, abdominal distension and/or delayed passage of flatus or stool which may occur following surgery. POI slows patient recovery, increases the risk of developing postoperative complications, and confers a significant financial load on healthcare institutions. 2. The aim of this revie...

The rapid urban expansion has greatly extended the physical boundary of users’ living area and developed a large number of POIs (points of interest). POI recommendation is a task that facilitates users’ urban exploration and helps them filter uninteresting POIs for decision making. While existing work of POI recommendation on location-based social networks (LBSNs) discovers the spatial, tempora...