Bone-targeted polymeric nanoparticles for alendronate delivery based on Poly (lactic-co-glycolic acid) conjugated chitosan (CS-PLGA) and PLGA (Alen-PLGA) are fabricated their superior performances evaluated. The exhibited sustained Alen release without obvious burst good cytocompatibility against MC3T3 cells. Alen-modified demonstrated a high affinity to hydroxyapatite, which is the main minera...