In vitro cell culture is traditionally performed within two-dimensional (2D) environments, providing a quick and cheap way to study cell properties in a laboratory. However, 2D systems differ from the in vivo environment and may not mimic the physiological cell behavior realistically. For instance, 2D culture models are thought to induce cancer stem cells (CSCs) differentiation, a rare cancer c...

The presented paper investigated the influence of brewers’ spent grain (BSG) extrusionparameters on photo-oxidative resistance poly(ε-caprolactone)-based wood polymer composites.Filler samples characterized by higher melanoidin content were more efficient in hindering polymerdegradation, inhibiting decomposition amorphous phase. As a result, deteriorationof mechanical performance was limited, w...

Zwitterionic polymers have unique features, such as good compatibility, and show promise in the application of drug delivery. In this study, the zwitterionic copolymers, poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) with disulfide (PCL-ss-PMPC) or poly(ε-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) or without disulfide (PCL-PMPC) and with different bloc...

Nanoformulations can play an important role in the improvement of anticancer drug therapies. The bioavailability sorafenib, which is exclusively applied treatment unresectable hepatocellular carcinoma, may be increased by its incorporation a biocompatible nanoparticulate matrix that capable targeting and controlling release. copolymers ε-caprolactone are emerging biodegradable compounds for del...

Mammalian central nervous system (CNS) neurons do not regenerate after injury due to the inhibitory environment formed by the glial scar, largely constituted by myelin debris. The use of biomaterials to bridge the lesion area and the creation of an environment favoring axonal regeneration is an appealing approach, currently under investigation. This work aimed at assessing the suitability of th...