Osteoarthritis scaffold-based grafts fail because of poor integration with the surrounding soft tissue and inadequate tribological properties. To circumvent this, we propose electrospun poly(ε-caprolactone)/zein-based scaffolds owing to their biomimetic capabilities. The scaffold surfaces were characterized using Fourier-transform infrared spectroscopy, X-ray photoelectron static water contact ...

A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineeri...

Asymmetric telechelic α-hydroxyl-ω-(carboxylic acid)-poly(ε-caprolactone) (HA-PCL), α-hydroxyl-ω-(benzylic ester)-poly(ε-caprolactone) (HBz-PCL) and an asymmetric telechelic copolymer α-hydroxyl-ω-(carboxylic acid)-poly(ε-caprolactone-co-γbutyrolactone) (HA-PCB) were synthesized by ring-opening polymerization of εcaprolactone (CL). CL and CL/γ-butyrolactone mixture were used to obtain homopolym...