Thiazoles derivatives are consisted in chemical compounds such as antimicrobial and anticancer medicine. Since polylactic-co-glycolic acid (PLGA) polymeric nanoparticles has been conversed about nanomedicine applications and particularly as drug delivery systems. Because of molecular self-assemblies and biodegradability of PLGA polymer, it can be used to carry anti-cancer and antimicrobial drug...

Herein we report preparation of polymeric monofunctional nanoparticles (PMNs) through intramolecularly cross-linking the polymer chains sparsely grafted on the surface of sacrificial silica spheres, and a one-to-one coupling reaction between PMNs and linear polymer chains and that between two PMNs.

Azobenzene-functionalized ABA triblock copolymers with controlled molecular weights are prepared first via a sequential ring-opening metathesis polymerization and acyclic diene metathesis polymerization in one-pot, which are readily converted, by a facile esterification, to the modified ABA triblock copolymers. Then, these reactive triblock copolymers can spontaneously self-assemble in a select...

Nanotechnology plays a significant role in drug development. As carriers, polymeric nanoparticles can deliver vaccine antigens, proteins, and drugs to the desired site of action. Polymeric nanoparticles with lower cytotoxicity can protect the delivered antigens or drugs from degradation under unfavorable conditions via a mucosal administration route; further, the uptake of nanoparticles by anti...

Cancer stem cells (CSCs) have been reported to play critical roles in tumor initiation, propagation, and regeneration of cancer. Nano-size vehicles are employed to deliver drugs to target the CSCs for cancer therapy. Polymeric nanoparticles have been considered as the most efficient vehicles for drug delivery due to their excellent pharmacokinetic properties. The CSCs specific antibodies or lig...

A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite nanoparticles were synthesized by chemical precipitation. The as-synthesized magnetite nanoparticles were subsequently introduced into a mixture of polymer magnetic polymeric ...

Noble metal nanoparticles of different sizes and shapes combined with conjugated functional polymers give rise to advanced core shell hybrids with interesting physical characteristics and potential applications in sensors or cancer therapy. In this paper, a versatile and facile synthesis of core shell systems based on noble metal nanoparticles (AuNPs, AgNPs, PtNPs), coated by copolymers belongi...

Due to unique applications of palladium nanoparticles, synthesis of these nanoparticles by a simple and low cost method is very important. In this work, Pd nanoparticles were synthesized with narrow size distribution by loading metal salt (Pd(OAc)2 ) into the polymeric matrix (PEG) as reducing agent and stabilizer. Also, the effect of metal salt concentration and PEG molecular weight on the con...

Magnetic CuFe2O4 nanoparticles were synthesized by a facile microwave-assisted reaction between Cu(NO3)2 and Fe(NO3)3. The magnetic nanoparticles were added to starch to make magnetic polymeric nanocomposite. The nanoparticles and nanocomposites were characterized using X-ray diffraction and scanning electron microscopy. The magn...