Cell migration determines the complete development of mammalian tissue and other pathological phenomena. To investigate effect chemical stimuli on such behavior, cells are triggered to translate by concentration gradient different molecules 2D substrates in vitro. But date unfortunately polymeric scaffolds for cell 3D environment with have not been proposed developed yet. Herein, a novel compos...

Three-dimensional (3D) printing technologies have reached a level of quality that justifies considering rapid manufacturing for medical applications. Herein, we introduce a new approach using 3D printing to simplify and improve the fabrication of human heart valve scaffolds by tissue engineering (TE). Custom-made human heart valve scaffolds are to be fabricated on a selective laser-sintering 3D...

Bioorthogonal catalysis using transition-metal-based complexes (TMCs) is a promising approach for converting substrates to desired products in complex cellular media. Notably, the situ activation of prodrugs or synthesis active drugs with aim complement existing treatments diseases such as cancer has received significant attention. Whereas focus initially been on optimizing ligands enhance acti...

tissue engineering based on the adipose derived stem cells  promote a strong strategy to propagation of bone, cartilage and fat tissues in the three-dimensional scaffolds, fabricated by combining biological materials with suitable and appropriate growth factors.  in this study, a peo scaffold was used to show that mesenchymal stem cells can attach well; the aim of this study was the investigati...

The accurate material modelling of poly-l-lactic acid (PLLA) is vital in conducting finite element analysis polymeric bioresorbable scaffolds (BRS) to investigate their mechanical performance and seek improved scaffold designs. To date, a large variety models have been utilised, ranging from simple elasto-plastic high fidelity parallel network models. However, no clear consensus has reached on ...

Covalent organic frameworks have emerged as a powerful synthetic platform for installing and interconverting dedicated molecular functions on crystalline polymeric backbone with atomic precision. Here, we present novel strategy to directly access amine-linked covalent frameworks, which serve scaffold enabling pore-wall modification linkage-interconversion by new methods based Leuckart–Wallach r...