نتایج جستجو برای: polymeric scaffold

تعداد نتایج: 47340  

Journal: :Biomedical Materials & Devices 2022

In this research, we developed strontium-substituted apatite (Sr-HAP) scaffolds using the polymeric sponge replication method. Tissue engineering is a potential new technology for replacing damaged tissue with biocompatible artificial templates. The prepared an interconnected porous microstructure pore sizes ranging from 400 to 622 μm were created as constructions. physicochemical properties of...

2014
Annapaola Parrilli Stefania Pagani Maria Cristina Maltarello Spartaco Santi Paolo Antonio Netti Roberto Giardino Lia Rimondini Milena Fini

Aims In orthopedic surgery the tissues damaged by injury or disease could be replaced using constructs based on biocompatible materials, cells and growth factors. Scaffold design, porosity and early colonization are key components for the implant success. From biological point of view, attention may be also given to the number, type and size of seeded cells, as well as the seeding technique and...

2013
Archana Sharma Sumrita Bhat Tanushree Vishnoi Vijayashree Nayak Ashok Kumar

A tissue-engineered polymeric scaffold should provide suitable macroporous structure similar to that of extracellular matrix which can induce cellular activities and guide tissue regeneration. Cryogelation is a technique in which appropriate monomers or polymeric precursors frozen at sub-zero temperature leads to the formation of supermacroporous cryogel matrices. In this study carrageenan-gela...

Journal: :Science and technology of advanced materials 2012
Roberto Scaffaro Giada Lo Re Salvatrice Rigogliuso Giulio Ghersi

We evaluated the combination of leaching techniques and melt blending of polymers and particles for the preparation of highly interconnected three-dimensional polymeric porous scaffolds for in vitro studies of human hepatocarcinoma processes. More specifically, sodium chloride and poly(ethylene glycol) (PEG) were used as water-soluble porogens to form porous and solvent-free poly(L,D-lactide) (...

Journal: :Tissue engineering. Part C, Methods 2012
Xin Cai Bhavna S Paratala Song Hu Balaji Sitharaman Lihong V Wang

Three-dimensional polymeric scaffolds provide structural support and function as substrates for cells and bioactive molecules necessary for tissue regeneration. Noninvasive real-time imaging of scaffolds and/or the process of tissue formation within the scaffold remains a challenge. Microcomputed tomography, the widely used technique to characterize polymeric scaffolds, shows poor contrast for ...

2014
Saravanan Manikam Sadasivam Sergey Ryazanov Andrei Leonov Armin Giese Christian Griesinger J. Antoinette Killian

partitioning is driven by the spatial recruitment of proteins to the cell pole in the bacterial model system Caulobacter crescentus. The polar organizing protein PopZ assembles as a polymeric network at one and then the opposite cell pole where it respectively anchors the original and the newly replicated DNA. Previous super-resolution imaging experiments in our lab have determined the cytosoli...

Journal: :Tissue engineering 2006
S Sahoo H Ouyang James C-H Goh T E Tay S L Toh

Unlike braided fabrics, knitted scaffolds have been proven to favor deposition of collagenous connective tissue matrix, which is crucial for tendon/ligament reconstruction. But cell seeding of such scaffolds often requires a gel system, which is unstable in a dynamic situation, especially in the knee joint. This study developed a novel, biodegradable nano-microfibrous polymer scaffold by electr...

Journal: :Acta biomaterialia 2014
Caroline Ceccaldi Raya Bushkalova Chiara Alfarano Olivier Lairez Denis Calise Philippe Bourin Celine Frugier Charlotte Rouzaud-Laborde Daniel Cussac Angelo Parini Brigitte Sallerin Sophie Girod Fullana

Three-dimensional (3D) scaffolds hold great potential for stem cell-based therapies. Indeed, recent results have shown that biomimetic scaffolds may enhance cell survival and promote an increase in the concentration of therapeutic cells at the injury site. The aim of this work was to engineer an original polymeric scaffold based on the respective beneficial effects of alginate and chitosan. For...

2017
Dario Puppi Andrea Morelli Federica Chiellini

Additive manufacturing of scaffolds made of a polyhydroxyalkanoate blended with another biocompatible polymer represents a cost-effective strategy for combining the advantages of the two blend components in order to develop tailored tissue engineering approaches. The aim of this study was the development of novel poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/ poly(ε-caprolactone) (PHBHHx/PCL) b...

Journal: :Acta biomaterialia 2009
Ana Rita C Duarte João F Mano Rui L Reis

The aim of this study was to evaluate the possibility of preparing dexamethasone-loaded starch-based porous matrices in a one-step process. Supercritical phase inversion technique was used to prepare composite scaffolds of dexamethasone and a polymeric blend of starch and poly(l-lactic acid) (SPLA) for tissue engineering purposes. Dexamethasone is used in osteogenic media to direct the differen...

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