background evidence indicates rfc1 g80a polymorphism as a risk factor for a number of cancers. increasing studies have been conducted on the association of rfc1 g80a polymorphism with acute lymphoblastic leukemia (all) risk. however, the results were  controversial. the aim of the present study was to derive a more precise estimation of the relationship.  materials and method pubmed, embase, we...

background: progesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. investigations have showed that polymorphism of progesterone receptor (pgr) is associated with some diseases. objective: to analyze the potential relationship between male infertility and the +331g/a and progins polymorphisms of pgr gene. materials and...

introduction: one factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (rsa) is c677t polymorphism of methylenetetrahydrofolate reductase gene. this study aimed to determine the association between rsa and mthfr c677t polymorphism in iranian patients. methods: in this case-control study, 30 patients with previous history of two or more consecutive unexpla...

background polymorphisms in the interferon λ (inf λ) genes on chromosome 19 have been associated with clearance of hepatitis c virus (hcv) induced by interferon and ribavirin therapy however there is no such data available for pakistani patients with hcv infection. objectives in this study, the effects of single nucleotide polymorphisms (snps) have been investigated in response to treatment wit...

Cytokines are secreted or membrane-bound proteins that act as mediators of intercellular signaling to regulate homeostasis the immune system. They produced by cells innate and adaptive immunity in response microbes tumor antigens. Although there several studies showing IL2-330 gene polymorphism is associated with many types cancer, far we know, a few study investigating association between lung...

Chloroform accumulation in the body and increase its steady-state concentrations blood of exposed people have been established to be associated with polymorphisms enzyme genes a genotype involved metabolism water disinfection byproducts (A415G EPHX1 gene, C1091T CYP2E1 zero mutations GSTT1 GSTM1 genes) (р < 0.000001). These correlate higher chloroform levels consuming chlorinated drinking wa...

dna polymorphism within diacylglycerol transferase 2 (dgat2) / monoacyl glycerol transferases 2 (mogat2), leptin and butyrophilin genes were analysed using pcr-sscp in murrah buffalo. the single strand conformation polymorphism (sscp) analysis of amplified gene fragment in exon 5 of mogat2, exon 3 of leptin and intron 1 of butyrophilin gene revealed different patterns. a, b and c showed the fol...

Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. In this study, we als...