A strategy is presented that allows a causal analysis of co-expressed genes, which may be subject to common regulatory influences. A state-of-the-art promoter analysis for potential transcription factor (TF) binding sites in combination with a knowledge-based analysis of the upstream pathway that control the activity of these TFs is shown to lead to hypothetical master regulators. This strategy...

Research Theme 1. Quantification of trace amount of proteins (Etsuro Ito, Mika Morikawa, Mugiho Kaneda) We are developing the method to detect and quantify very tiny amount of a given protein in a small volume, such as in a single cell. We aim at establishing an enterprise to commercialize protein quantification reagents and kits based on this technique. Using our “enzyme cycling method”, it is...

[1] We present a novel explanation of the physical processes behind one type of cloud and ground-level tornadogenesis within a supercell. We point out that the charge separation naturally found in these large thunderstorms can potentially serve to contract the preexisting angular momentum through the additional process of the electric force. On the basis of this, we present a plausible geometry...

Homomorphic signatures (HS) allows the derivation of the signature of the message-function pair (m, g), where m = g(m1, . . . ,mK), given the signatures of each of the input messages mk signed under the same key. Multi-key HS (M-HS) introduced by Fiore et al. (ASIACRYPT’16) further enhances the utility by allowing evaluation of signatures under different keys. While the unforgeability of existi...

Recent developments in voting theory show that Condorcet profiles embedded in electorates are responsible for conflicts between pairwise voting methods and for reversals of rankings under positional methods whenever candidates are dropped or added. Because of the strong symmetry of the rankings of the candidates within these profiles, it can be argued that Condorcet profiles represent complete ...

Cancer is an evolutionary process characterized by the accumulation of somatic mutations in a population of cells that form a tumor. One frequent type of mutations are copy number aberrations, which alter the number of copies of genomic regions. The number of copies of each position along a chromosome constitutes the chromosome’s copy-number profile. Understanding how such profiles evolve in ca...

Demange (2012) generalized the classical singlecrossing property to the intermediate property on median graphs and proved that the representative voter theorem still holds for this more general framework. We complement her result with proving that the linear orders of any profile which is intermediate on a median graph form a Condorcet domain. We prove that for any median graph there exists a p...

In this article an analytical technique, namely the homotopy analysis method (HAM), is applied to solve the momentum and energy equations in the case of a two-dimensional incompressible flow passing over a wedge. The trail and error method and Padé approximation strategies have been used to obtain the constant coefficients in the approximated solution. The effects of the polynomial terms of HAM...

Matrix functions are used in many areas of linear algebra and arise in numerical applications in science and engineering. In this paper, we introduce an effective approach for determining matrix function f(A)=g(q(A)) of a square matrix A, where q is a polynomial function from a degree of m and also function g can be a transcendental function. Computing a matrix function f(A) will be time- consu...