Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous, naturally occurring molecules. They form a recently identified class of compounds derived from ATP and consist of two adenosine molecules bridged by up to six phosphate groups. These compounds are stored in high concentrations in platelet dense granules and are released when platelets become ac...

des Polyphosphates EUROPEAN CHEMICAL INDUSTRY COUNCIL Dr. Jonathan Köhler Department of Applied Economics University of Cambridge, UK. This report was prepared by Dr. Jonathan Köhler, Department of Applied Economics University of Cambridge, UK, for the Centre Européen d'Etudes des Polyphosphates, the Western European phosphate industry's joint research association (a European Chemical Industry ...

Development of effective, yet safe, antithrombotic agents has been challenging because such agents increase the propensity of patients to bleed. Recently, naturally occurring polyphosphates such as extracellular DNA, RNA, and inorganic polyphosphates have been shown to activate blood coagulation. In this report, we evaluate the anticoagulant and antithrombotic activity of nucleic acid-binding p...

A complex mixture of fluoro-polyphosphates (FPPs) and polyphosphates was prepared by heating a mixture of NaF and sodium tripolyphosphate (STPP) at 600 8C in nitrogen atmosphere. Two-dimensional P–F heteronuclear correlation spectroscopy (HETCOR) NMR was developed in identifying the atomic connection between F and P in the mixed FPPs. F, P and P–P correlation spectroscopy (COSY) NMR methods wer...

Polyphosphate (Poly-P) accumulation has been reported in Chlorella vulgaris under nitrogen deficiency conditions with sufficient P supply, and the process has been demonstrated to have great impact on lipid productivity. In this article, the utilization of polyphosphates and the regreening process under N resupplying conditions, especially for lipid production reviving, were investigated. This ...

Inorganic polyphosphates, linear polymers of orthophosphate, occur naturally throughout biology and have many industrial applications. Their biodegradable nature makes them attractive for a multitude of uses, and it would be important to understand how polyphosphates are turned over enzymatically. Studies of inorganic polyphosphatases are, however, hampered by the lack of high-throughput method...

High resolution (31)P nuclear magnetic resonance spectra at 303.6 MHz (corresponding to a (1)H resonance frequency of 750 MHz) have been obtained of perchloric acid extracts of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, the causative agents of African sleeping sickness, Chagas' disease, and leishmaniasis. Essentially complete assignments have been made based on chemical shifts...

Inorganic polyphosphates are long chains of a few to several hundred phosphate residues linked by phosphoanhydride bonds (Figure 1). Polyphosphates have been found in all cell types examined to date and have been demonstrated to play diverse roles depending on the cell type and circumstances (Kornberg et al., 1999; Kulaev & Kulakovskaya, 2000). The biological roles played by polyphosphates have...