Growth of intact bacterial plaques associated with dental caries and peridontal disease is inhibited by some polyphosphates.

OBJECTIVE Diadenosine polyphosphates have been demonstrated to be involved in the control of vascular tone as well as the growth of vascular smooth muscle cells and hence, possibly, in atherogenesis. In this study we investigated the question of whether diadenosine polyphosphates are present in human plasma and whether a potential source can be identified that may release diadenosine polyphosph...

The determination of myo-inositol trisphosphate by an enzymatic fluorometric assay is presented. The method involves the acid extraction of water-soluble inositol polyphosphates followed by separation by anion-exchange chromatography. Samples are subsequently neutralized by passage over a Dowex Cl- resin and elution with lithium chloride. Samples are then desalted with ethanol. Following dephos...

Inositol polyphosphates, in their water-soluble or lipid-bound forms, represent a large and multifaceted family of signalling molecules. Some inositol polyphosphates are well recognised as defining important signal transduction pathways, as in the case of the calcium release factor Ins(1,4,5)P3, generated by receptor activation-induced hydrolysis of the lipid PtdIns(4,5)P2 by phospholipase C. T...

© Schattauer 2012 Thrombosis and Haemostasis 108.4/2012 Recent findings indicate that naturally occurring polyphosphates, like nucleic acids and inorganic compounds, share the ability to trigger blood coagulation (1). The release of DNA or RNA by tissue damage can thus represent a first line of haemostatic defence against vascular injury. This view is further corroborated by the observation tha...