We studied the genetic restrictions on the interaction between T cells, B cells, and antigen-presenting cells (APC) involved in the H-2-linked Ir gene control of the in vitro secondary antibody response to sperm whale myoglobin (Mb) in mice. The B cells in this study were specific for Mb itself, rather than for a hapten unrelated to the Ir gene control, as in many previous studies. Low responde...

The most common ocular side effect of glucocorticoid (GC) therapy is GC-induced ocular hypertension (OHT) and GC-induced glaucoma (GIG). GC-induced OHT occurs in about 40% of the general population, while the other 60% are resistant. This study aims to determine the genes and pathways involved in differential GC responsiveness in the trabecular meshwork (TM). Using paired bovine eyes, one eye w...

Erythrocytes from the same mouse strains gave similar results; here the cell number was increased to 109/ml to obtain a significant difference between curves for highand low-responder mice. It is possible that these results are affected by contamination with mouse ferritin from the spleen or plasma despite washing of cells. To minimize possible contamination by mouse ferritin, lymph-node cells,...

In their opinion article within this issue of Human Reproduction, Polyzos and Sunkara propose to create a new, presumed clinically relevant, ovarian response category (Polyzos and Sunkara, 2015). Today, the poor responder is indisputably recognized as problematic, as the far below average prognosis for live birth, especially in women of higher age, sheds doubt on the added value of assisted rep...

Abstract Study question Does the measurement of AMH isoforms in low ovarian reserve patients improve prediction number oocytes after stimulation (OS)? Summary answer assays measuring a broader range combined with antral follicle count (AFC) collected OS. What is known already Granulosa cells secrete as non-active prohormone (proAMH). After cleavage, it forms complex (AMHN,C) which activates rec...

Previous studies had shown that sub-inhibitory concentrations of silver sulphadiazine (AgSD) stimulated the production of Toxic Shock Syndrome Toxin-1 in certain strains (responder strains) of Staphylococcus aureus and that protease production was also affected. No changes were detected in other strains (non-responders). Extracellular proteins from eleven responder and non-responder strains gro...