Munc18-1 plays pleiotropic roles in neurosecretion by acting as 1) a molecular chaperone of syntaxin-1, 2) a mediator of dense-core vesicle docking, and 3) a priming factor for soluble N-ethylmaleimide-sensitive factor attachment protein receptor-mediated membrane fusion. However, how these functions are executed and whether they are correlated remains unclear. Here we analyzed the role of the ...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

objective(s): recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. the ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. therefore, in the present study, a series of 19 compo...

This is the first study to attempt to explain income inequality using unemployment and inflation and international cross-sectional data. Using a SURE system, inflation is found to have an increasing impact on the shares of the lower 80% of the income distribution, while reducing the share of the highest 20%. Unemployment has a negative effect on the share of the first 40%, while increases the s...

A database consisting of 780 ligand-receptor complexes, termed SB2010, has been derived from the Protein Databank to evaluate the accuracy of docking protocols for regenerating bound ligand conformations. The goal is to provide easily accessible community resources for development of improved procedures to aid virtual screening for ligands with a wide range of flexibilities. Three core experime...

One of the strategic objectives supply chains in automotive industry is development international sourcing. Renault works with a global network cross-docking platforms to link distant assembly plants first-tier suppliers. These act both as information and physical consolidation points. At shop-floor, inland deliveries are received, sorted, repacked (if needed) loaded onto containers for oversea...

The management of trucks in a cross-docking platform is a process under five steps: the arrival, the control, the unloading, the transfer and finally the loading. In each of these steps, a sequence of decisions arise. To achieve an optimal and robust solutions, the interdependencies between the different planning functions should be taken into account, and scheduling decisions must be made simu...

introduction: many studies have been performed to evaluate the stress distribution around endodontic posts; those which compared posts composed of different materials are rare. the aim of this study was to compare stresses induced in dentin by three structurally different posts using photoelasticity method. materials and methods: nine blocks of psm-5 photoelastic material with 45×45×10 mm dimen...

Introduction: The restoration material commonly used as core material for pulpless posterior teeth is mostly amalgam due to its high strength and low cost and it can be used with or without pin. The aim of this study was to evaluate the influence of post material on stress distribution in mandibular second premolar tooth by finite element analysis. Method: The stress distribution was analyzed i...

Lead optimization benefits from including structural knowledge of the target. We present a new method that exploits quantitatively NMR amide proton chemical shift perturbations (CSP) on the protein side for protein-ligand docking. The approach is based on a hybrid scoring scheme consisting of a weighted sum of DrugScore, describing protein-ligand interactions, and Kendall's rank correlation coe...