BACKGROUND Protein-protein recognition is of fundamental importance in the vast majority of biological processes. However, it has already been demonstrated that it is very hard to distinguish true complexes from false complexes in so-called cross-docking experiments, where binary protein complexes are separated and the isolated proteins are all docked against each other and scored. Does this re...

T cells are known to cross-react with diverse peptide MHC Ags through their alphabeta TCR. To explore the basis of such cross-reactivity, we examined the 2C TCR that recognizes two structurally distinct ligands, SIY-K(b) and alloantigen QL9-L(d). In this study we characterized the cross-reactivity of several high-affinity 2C TCR variants that contained mutations only in the CDR3alpha loop. Two ...

Cross docking is a form of operating break-bulk freight terminals in which the receiving products are not stocked but, instead, the incoming cargo is internally transferred to be immediately shipped in distribution trucks. With this approach, inventory costs and lead-times are significantly reduced. In this work, an approximate, continuous, non-stationary queueing model is established to estima...

Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at ...

<1> Accession Number 20143035112 Author Fadeyemi, A. J. Title Tail docking in dogs: evaluation of current practices and ethical aspects in southwest Nigeria. Source Journal of Veterinary Medicine and Animal Health; 2014. 6(1):18-24. 21 ref. Publisher Academic Journals Location of Publisher Nairobi Country of Publication Kenya Abstract This study evaluated the current practices of tail docking i...

Although some docking methods accounting for protein flexibility exist, most large scale virtual screening approaches work with rigid protein models. A first step towards flexibility integration is the consideration of degrees of freedom resulting from hydrogens, especially, if involved in hydrogen bonding. To account for this type of flexibility, we present a flexible-hydrogen interaction mode...

In the last years, the importance of water molecules in pose prediction experiments has been widely recognized and several approaches to integrate water molecules into the docking process have been proposed [1,2]. The inclusion of water molecules extends the classical two-body problem of docking a flexible ligand into a protein receptor to a multi-body docking problem as protein-ligand, protein...

background: this study aimed to evaluated trends for iron and manganese concentrations in wells, reservoirs, and water distribution networks in qom city during the summer of 2012. methods: this was a cross-sectional study. the studied scopes consisted of groundwater (60 wells), reservoirs (10 tanks), and water distribution network (33 points). one sample was taken from each source monthly. stat...