background: early childhood caries (ecc) in the earliest stage is preventable. the studies indicate oral bacteria play an important role in pathogenesis of dental caries. according to high prevalence of ecc, alternative therapies should be explored in order to reduce the occurrence of it. aim: this study aims to assess the effectiveness of a product containing povidone iodine 10% and sodium flu...

one of the most significant issues in pharmaceutical industries, prior to commercializationof a pharmaceutical preparation is the “preformulation” stage. however, far too attention hasbeen paid to verification of the software assisted statistical designs in preformulation studies.the main aim of this study was to report a step by step preformulation approach for a semisolidpreparation based on ...

Acidic electrolysed water (AEW) is a colorless solution prepared by the electrolysis of sodium chloride solution, which has potent anti-microbial activity against a wide variety of bacteria, fungi and virus. In this study, the safety and efficacy of an isotonic AEW solution (iAEW) was investigated both in vitro and in vivo using denuded corneas of guinea pigs. Povidone iodine (0.01-1.0%) was us...

INTRODUCTION The management of recurrent pleural effusion or pneumothorax has always been a cause for serious concern among chest physicians. Among the wide variety of agents that are available for pleurodesis, povidone iodine is now perhaps the most sought after agent as it is cheap, easily available, effective and safe. This study was conducted to establish the efficacy and safety of povidone...

BACKGROUND To determine the efficacy of different antiseptic solutions (Control group (I), Antibiotic solution (II), Chlorhexidine 0.4% (III), and povidone - iodine 10% (IV)) in sterilizing contaminated osteochondral plugs. METHODS Under sterile conditions, the femoral head and condyles of 20 rabbits were removed and cut into equal osteochondral pieces. A total of 200 osteochondral specimens ...

PURPOSE To determine the conjunctival bacterial flora in cataract surgery patients and the effect of presurgical irrigation with 5% povidone-iodine solution. METHODS Three samples from the inferior conjunctival fornix of the eye to be operated were obtained at baseline before washing (T0) with 10 ml 5% povidone-iodine solution, immediately after washing (T1), and upon completion of surgery (T...

OBJECTIVES To test the effects of several biocides [N-propanol, a commercially available propanol/ethanol/chlorhexidine mixture, polyvinylpyrolidone (povidone-iodine) and hydrogen peroxide] on established biofilms of Staphylococcus epidermidis isolated from patients with cardiac implant infections and catheter-related bacteraemia. METHODS Biofilms were grown in microtitre plates for 24 h, dye...

Background: Mechanical ventilation is often required in 10-20% critically ill patients, may be because of respiratory or any other indication. There is always a risk of developing pneumonia in such patients. Any pneumonia developing after 48 hours of commencing mechanical ventilation in a patient with previously non infected lungs is labeled as ventilator associated pneumonia (VAP).It occurs in...

BACKGROUND Catheter-related exit site infection is a major risk factor for the development of peritonitis and can contribute to failure of treatment maintenance in peritoneal dialysis (PD) patients. Although povidone-iodine can be used for exit site care, the irritation induced by the local application of povidone-iodine could lead to secondary infection. Therefore, we evaluated the clinical ef...

BACKGROUND Currently, there are various antiseptics used for cleaning the skin before surgery, but there is no standard procedure in practice. Chlorhexidine and povidone-iodine are the most preferred compounds among antiseptics. Both are proved to be safe and effective for skin disinfection. In this study, our aim was to investigate the combined effects of chlorhexidine and povidone-iodine on t...