نتایج جستجو برای: pparα genotypes

تعداد نتایج: 57885  

Journal: :journal of nutritional sciences and dietetics 0
hamideh pishva department of cellular, molecular nutrition, school of nutrition sciences and dietetics, tehran university of medical sciences, tehran, iran soltanali mahboob nutrition research center, tabriz university of medical sciences, tabriz, iran mohammadreza eshraghian department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran

ba ckground: obesity is a consequence of the excessive accumulation of fat in adipose tissue which can result in significant morbidity and mortality. obesity is a major health problem in iran.  objective: the aim of this study was to investigate the  effects of  epa consumption on bmi  and  fasting blood sugar by fabp2 genotypes and pparα (leu162val, and g/c intron polymorphism) genotypes.   m ...

2017
Bernadett Márkus Krisztián Vörös Dorina Supák Zsolt Melczer Károly Cseh László Kalabay

BACKGROUND Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. AIMS We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations. PATIENTS AND METHODS The PPARα intron 7 G/C polymorphism was studied in cohort 1 (79 reference individuals, 165 postinfar...

2014
Hamideh Pishva Parvin Mehdipour Mohammad Reza Eshraghian Soltan-Ali Mahboob

BACKGROUND We determined the blood lipid-lowering effects of eicosapentaenoic acid (EPA) on hypertriglyceridemic subjects with Leu162/Val in exon 5 and G/C in intron7 polymorphism of peroxisome proliferator-activated receptor alpha (PPARα)genotypes that, to our knowledge, have not been previously studied. METHODS A total of 170 hypertriglyceridemic subjects were enrolled and genotyped for Ala...

2015
Qi Ling Xiao Xu Kai Wang Chao Wang Penghui Xiang Xuanyu Zhang Runzhou Zhuang Haiyang Xie Shusen Zheng Lin. Wenyu

Peroxisome proliferator-activated receptor α (PPARα) is an important regulator of glucose and lipid metabolism, and is predominantly expressed in the liver. We aimed to evaluate the effect of donor hepatic PPARα gene polymorphisms on the development of metabolic disorders following liver transplantation (LT).A total of 176 patients undergoing primary LT were included in this Review Board-approv...

2011
Shi Hyun Kang Jong Il Lee An Kee Chang Yeon Ho Joo Chang Yoon Kim Seong Yoon Kim

OBJECTIVE Genetic variation in the serotonin-2C receptor encoded by the HTR2C gene is one of the genetic determinants of antipsychotic-induced weight gain. Peroxisome proliferator-activated receptors are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. In this cross-sectional study, we investigated whether HTR2C-759C/T, HTR2C-697G/C, PPARα V227A, an...

Feyzollahi, Foad, Ghani, Bahare, Mohsenzadeh, Mahsa,

Backgrond: Although some studies have studied the mechanism of action of beta cells in animal models and more or less in human populations, but so far the role of exercise therapy or exercise exercise HIIT along with black grape supplementation on the expression of involved genes Less has been studied in pancreatic beta cells, so the aim of the present study was to investigate the effect of eig...

2016
Alexandra Montagner Arnaud Polizzi Edwin Fouché Simon Ducheix Yannick Lippi Frédéric Lasserre Valentin Barquissau Marion Régnier Céline Lukowicz Fadila Benhamed Alison Iroz Justine Bertrand-Michel Talal Al Saati Patricia Cano Laila Mselli-Lakhal Gilles Mithieux Fabienne Rajas Sandrine Lagarrigue Thierry Pineau Nicolas Loiseau Catherine Postic Dominique Langin Walter Wahli Hervé Guillou

OBJECTIVE Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed in tissues with high oxidative activity that plays a central role in metabolism. In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD). DESIGN We constructed a novel hepatocyte-specific PPARα knockout (Pparα(hep-/-)) mouse model. Using this novel m...

Journal: :Cerebrovascular diseases 2016
Yeqing Tong Li Cai ShengHong Han Qing Lu Xuhua Guan Xiaoxv Ying Shuangyi Hou Fanxian Zhan Jin-quan Cheng Jiafa Liu

BACKGROUND PPARx03B3; and PPARα belong to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). METHODS One thousand two hundred ninety-six subjects from the Chinese Han Populat...

2016
Rui Cheng Lexi Ding Xuemin He Yusuke Takahashi Jian-xing Ma

Peroxisome proliferator-activated receptor-α (PPARα) displays renoprotective effects with an unclear mechanism. Aberrant activation of the canonical Wnt pathway plays a key role in renal fibrosis. Renal levels of PPARα were downregulated in both type 1 and type 2 diabetes models. The PPARα agonist fenofibrate and overexpression of PPARα both attenuated the expression of fibrotic factors, and su...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Fanny Lalloyer Kristiaan Wouters Morgane Baron Sandrine Caron Emmanuelle Vallez Jonathan Vanhoutte Eric Baugé Ronit Shiri-Sverdlov Marten Hofker Bart Staels Anne Tailleux

OBJECTIVE Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor that controls lipid metabolism and inflammation. PPARα is activated by fibrates, hypolipidemic drugs used in the treatment of dyslipidemia. Previous studies assessing the influence of PPARα agonists on atherosclerosis in mice yielded conflicting results, and the implication of PPARα therein...

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