BACKGROUND ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis) are marine derived compounds that have antitumor activity. ET-743 and PM00104 exposure over sustained periods of treatment will result in the development of drug resistance, but the mechanisms which lead to resistance are not yet understood. METHODOLOGY/PRINCIPAL FINDINGS Human chondrosarcoma cell lines resistant to ET-743 (CS-1...

A diurnal change of tuberoinfundibular dopaminergic (TIDA) neuronal activity exists in female rats, which is prerequisite for the estrogen-induced afternoon PRL surge. Because progesterone (P4) administered in the morning can advance and amplify the PRL surge, it is of interest to learn whether its action involves the TIDA neuron. In adult ovariectomized and estrogen-primed Sprague-Dawley rats,...

OBJECTIVE Lacunar infarctions are mainly due to 2 microvascular pathologies: lipohyalinosis and microatheroma. Little is known about risk factor differences for these subtypes. We hypothesized that diabetes and glycated hemoglobin (HbA(1)c) would be related preferentially to the lipohyalinotic subtype. METHODS We performed a cross-section analysis of the brain MRI data from 1,827 participants...

This study was designed to investigate the protective role of protein (Pr) and calcium (Ca) on effects of fluoride (F) induced in nonspecific immunological function in New Zealand rabbits fed a Pr and a Ca nutritionally deficient (malnutrition) diet. Eighty healthy 30-day-old rabbits (1.07±0.25 kg) were divided randomly into four equal groups of twenty (female:male = 1:1). The four groups were ...

We study combinatorial principles known as stick and club. Several variants of these principles and cardinal invariants connected to them are also considered. We introduce a new kind of side-by-side product of partial orderings which we call pseudo-product. Using such products, we give several generic extensions where some of these principles hold together with ¬CH and Martin’s Axiom for counta...

The coordination chemistry of actinide(IV) ions with hydroxypyridinone ligands has been initially explored by examining the complexation of Th(IV) ion with bidentate PR-1,2-HOPO (HL1), PR-Me-3,2-HOPO (HL2), and PR-3,4-HOPO-N (HL3) ligands. The complexes Th(L)4, Th(L)4, and Th(L)4 were prepared in methanol solution from Th(acac)4 and the corresponding ligand. Single-crystal X-ray diffraction ana...

Background and Aims: Post exercise proteinuria and increased urinary Gamma-Glutamyl transferase (GGT) levels can be indicative of exercise-induced renal damage. The aim of this investigation was to study the effect of one session of intensive training on renal tubular injury markers and compare their values to those 6 hours after training, for evaluating tubular damage after intensive ...

BACKGROUND The 1-minute sit-to-stand (STS) test could be valuable to assess the level of exercise tolerance in chronic obstructive pulmonary disease (COPD). There is a need to provide the minimal important difference (MID) of this test in pulmonary rehabilitation (PR). METHODS COPD patients undergoing the 1-minute STS test before PR were included. The test was performed at baseline and the en...

H. Moriguchi, M. A. Griswold, J. L. Sunshine, J. L. Duerk Radiology, University Hospitals of Cleveland / Case Western Reserve University, Cleveland, OH, United States Introduction: Projection reconstruction (PR) acquisitions have re-emerged in MRI since they have several advantages over rectilinear acquisition methods. First, images reconstructed from PR acquisitions show reduced motion artifac...

Progesterone plays important roles in the regulation of female reproduction. In this study, progesterone receptor (PR) mRNA levels in rat uterus during pregnancy, labor, lactation and the estrous cycle were examined by competitive RT-PCR. During pregnancy and lactation, PR mRNA levels had decreased on day 20 of pregnancy (P20) and P21 compared with P15 but increased during labor. After a declin...