PURPOSE To review prevalence, long-term progression, and prognosis of vitreoretinal interface modifications in pathologic myopia with posterior staphyloma and investigate foveal sensitivity and fixation stability. METHODS Retrospective single-institution series of 214 eyes (116 patients) with pathologic myopia, axial length >30 mm, and posterior staphyloma. Exclusion criteria included follow-...

Assessing and managing water use is crucial for supporting sustainable river basin management and regional development. The first consistent and comprehensive assessment of sectorial water use in the Pearl River Delta (PRD) is presented by analysing homogenized annual water use data from 2000 to 2010 in relation to socio economic statistics for the same period. An abstraction of water use, usin...

Despite the considerable reductions in primary and secondary air pollutants China, surface ozone levels have increased recent years. We report a trend of 3.3 ± 4.7 ?g.m ?3 year ?1 annual mean maximum daily average over an 8-h period (MDA8 ozone) across China between 2015 2019. Leveraging Kolmogorov–Zurbenko filter method, we find that meteorology enhanced Beijing–Tianjin–Hebei (BTH), Yangtze Ri...

Although most L-type calcium channel alpha(1C) subunits isolated from heart or brain are approximately 190-kDa proteins that lack approximately 50 kDa of the C terminus, the C-terminal domain is present in intact cells. To test the hypothesis that the C terminus is processed but remains functionally associated with the channels, expressed, full-length alpha(1C) subunits were cleaved in vitro by...

Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and that this can be passed to subsequent generations. In the rat, induction of an altered metabolic phenotype in the liver of the F1 generation by feeding a protein-restricted diet (PRD) during pregnancy involves the altered methylation of s...

Satellite remote sensing offers an effective approach to estimate indicators of air quality on a large scale. It is critically significant for air quality monitoring in areas experiencing rapid urbanization and consequently severe air pollution, like the Pearl River Delta (PRD) in China. This paper starts with examining ground observations of particulate matter (PM) and the relationship between...

The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 functions as a general activator of ATR. However, the mechanism by which TopBP1 activates ATR is unknown. Here, we show that ATRIP contains a TopBP1-interacting region that is necessary for the association of TopBP1 and ATR...

Temperature compensation of circadian period length in 12 clock mutants of Neurospora crassa has been examined at temperatures between 16 and 34 degrees C. In the wild-type strain, below 30 degrees C (the "breakpoint" temperature), the clock is well-compensated (Q(10) = 1), while above 30 degrees C, the clock is less well-compensated (Q(10) = 1.3). For mutants at the frq locus, mutations that s...