Pax proteins are transcriptional regulators controlling a variety of cell fates during animal development. This role depends on the intact function of the paired (Prd) domain that is able to recognize specific DNA sequences. The Prd domain is composed of two distinct helix-turn-helix subdomains, PAI and RED. Molecular functions of Pax proteins are subjected to different levels of regulation inv...

This chapter presents the Late Quaternary neo-tectonic movement in the Pearl River Delta (PRD) region of China and its effects on the coastal sedimentary environment. Taking the Xilin Hill fault as the example, we have explained the reason of the PRD formation, inferred its interactions with local/regional climate and sea-level changes, and analyzed the evolution of the PRD formation and its co...

The objective of this study was to develop simple, precise, accurate, reproducible and economical vireodt's method for simultaneous estimation of mesalamine (MSM) and prednisolone (PRD) in combined oral dosage form. The method involved measurement of absorbance at two wavelengths, 332nm and 246nm, λmax of MSM and PRD, respectively in phosphate buffer (pH 7.4) with dimethyl formamide (DMF) as co...

Development and use of crop growth models is an effective tool for agricultural planningand decision making in agricultural industry. Besides, the drought and limited supplies of waterin many areas of the world has increased attention to favourable strategies in farm managementsuch as efficient irrigation and planting methods. The objective of this study was to develop acrop model for safflower...

Phosphatidylinositol-3 kinase-related kinases (PIKKs) comprise a family of protein kinases that respond to various stresses, including DNA damage, blocks in DNA replication, availability of nutrients and errors in mRNA splicing. PIKKs are characterized by the presence of a conserved kinase domain (KD), whose activity is regulated by two C-terminal regions, referred to as PIKK-regulatory domain ...

High order sliding mode controller (HOSMC) is proposed for blood glucose regulation. With this aim a novel concept of Practical Relative Degree (PRD) and a method of its identification are suggested. First, for PRD identification method is applied for the most simple (Bergman Minimal Model) and the most complicated (Sorensen Model) models concluding that the common PRD for both models is three....

This study examines whether subgroups of Black youth exist based on the presence or absence of racial discrimination experiences in the school context and whether these groups varied by gender and household income. Latent transition analyses were performed on racial discrimination indicators derived when youth were in the 8th and 11th grades. Three distinct subgroups of youth emerged. Youth in ...

The evolutionarily conserved paired domain consists of the N-terminal PAI and the C-terminal RED domains, each containing a helix-turn-helix motif capable of binding DNA. Despite its conserved sequence, the physiological functions of the RED domain remain elusive. Here, we constructed a prd transgene expressing a truncated Paired (Prd) protein without the RED domain, and examined its rescue abi...

Targeting of membrane proteins into the lysosomal/vacuolar lumen for degradation requires their prior sorting into multivesicular bodies (MVB). The MVB sorting pathway depends on ESCRT-0, -I, -II, and -III protein complexes functioning on the endosomal membrane and on additional factors, such as Bro1/Alix and the ubiquitin ligase Rsp5/Nedd4. We used the split-ubiquitin two-hybrid assay to analy...

TIA-1 is an RNA binding protein that promotes the assembly of stress granules (SGs), discrete cytoplasmic inclusions into which stalled translation initiation complexes are dynamically recruited in cells subjected to environmental stress. The RNA recognition motifs of TIA-1 are linked to a glutamine-rich prion-related domain (PRD). Truncation mutants lacking the PRD domain do not induce spontan...