on Puerperal Eclampsia. In one of the issues of the B. M. J. or Lancet last year an article appeared strongly advocating nitroglycerine liypodermically and by the mouth, specially the former. One very severe case recovered in this hospital under this treatment. Delivery was effected as rapidly as possible. Mins. ii of a 1% Soln. of Nitroglycerine were injected every two or three hours. Chlorofo...

In a paper contributed by us to the Indian Medical Gazette in 1922 we submitted an analysis of 450 cases of eclampsia treated at the Madras Maternity Hospital between the years 1908 and 1922, and then touched thereln on some factors which we thought weie of Primary importance in the treatment of the disease. Since the publication of this papei, we have had under our treatment a large numbei cas...

BACKGROUND Risk prediction models may be valuable to identify women at risk of pre-eclampsia to guide aspirin prophylaxis in early pregnancy. OBJECTIVE To assess the performance of 'simple' risk models for pre-eclampsia that use routinely collected maternal characteristics; compare with 'specialised' models that include specialised tests; and to guideline recommended decision rules. SEARCH ...

OBJECTIVE To investigate the predictive value of the combination of first-trimester serum placental protein 13 (PP13), uterine artery Doppler pulsatility index (PI) and pulse wave analysis (augmentation index at a heart rate of 75 beats per min (AIx-75)), and to evaluate concurrent and contingent strategies using this combination for assessing the risk of pre-eclampsia in high-risk women. MET...

Background and Purpose—Women who develop pre-eclampsia in pregnancy are at increased risk of cardiovascular disease. The offspring from pregnancies complicated by pre-eclampsia have higher blood pressures during childhood, but little is known about their long-term health. We hypothesized that pre-eclampsia would lead to an increased risk of cardiovascular disease in the offspring. Methods—We tr...

OBJECTIVE Pre-eclampsia, which is a major cause of perinatal and maternal morbidity and mortality, is thought to be due to impaired perfusion of the placenta. There is contradictory evidence that the administration of low-dose aspirin may provide effective prophylaxis against the subsequent development of pre-eclampsia. In this study we tested the hypothesis that in women identified as being at...

OBJECTIVE To develop a practical evidence based list of clinical risk factors that can be assessed by a clinician at ≤ 16 weeks' gestation to estimate a woman's risk of pre-eclampsia. DESIGN Systematic review and meta-analysis of cohort studies. DATA SOURCES PubMed and Embase databases, 2000-15. ELIGIBILITY CRITERIA FOR SELECTING STUDIES Cohort studies with ≥ 1000 participants that evalua...

If countries are to achieve the Millennium Development Goal (MDG) 4 (reducing maternal mortality) and MDG5 (reducing child mortality), donors and governments must develop comprehensive and innovative programs to address PE/E as public health priorities. This program guidance document outlines key steps, identifies available resources, and highlights lessons learned to date in the development an...

BACKGROUND Pre-eclampsia is a syndrome of heterogeneous origin characterized by deficient placentation due to the inability of the cytotrophoblast to acquire an invasive phenotype and to remodel the uterine spiral arteries. One of the main problems observed early in pre-eclampsia is an altered regulation of the immune system, where the shift toward a Th2 cytokine profile observed in normal preg...