Objective: Obesity is a major health problem. Nowadays approximately one-third of the world population suffer from obesity which is frequently accompanied with serious medical and emotional problems. Three main evidence-based options exist for the treatment of obese individuals: lifestyle modification, pharmacotherapy, and bariatric surgery. The purpose of this study was to ...

Based on our earlier studies in Japan [1, 2], we understand that we need to be more tolerant for the gestational weight gain in Japanese woman than ever, especially in overweight women. However, we have not well examined the influence of the maternal pre-pregnancy physique on the perinatal outcomes in the overweight and/or obesity women in Japan. To date, some pre-pregnancy body mass indexes (B...

Obesity is a common disorder affecting millions of people worldwide. The number overweight and obese subjects, globally, currently 2 billion 800 million, respectively. Projected estimates show that the citizens will approach 60% world’s population by year 2030. Oxidative stress facilitates development obesity stimulating pre-adipocyte differentiation eventual adipose accumulation. Large deposit...

BACKGROUND Worldwide there has been a dramatic increase in the prevalence of overweight and obesity in women of childbearing age. Growing evidence suggests that maternal overweight and obesity is associated with poor maternal and perinatal outcomes. This study evaluated the impact of maternal pre-pregnancy overweight and obesity on pregnancy, labour and delivery outcomes in a cohort of women wi...

The Communities for Healthy Living program used a community-based participatory research (CBPR) approach to empower Head Start parents in designing and pilot testing a multi-component family-centered obesity prevention program. One program component was a childhood obesity awareness campaign addressing common parental misconceptions about obesity. The campaign was designed by a community adviso...

This paper draws together contributions to a scientific table discussion on obesity at the European Science Open Forum 2008 which took place in Barcelona, Spain. Socioeconomic dimensions of global obesity, including those factors promoting it, those surrounding the social perceptions of obesity and those related to integral public health solutions, are discussed. It argues that although scienti...

Proinflammatory cytokines secreted from adipose tissue contribute to the morbidity associated with obesity. IL-1α is one of the proinflammatory cytokines; however, it has not been clarified whether IL-1α may also cause obesity. In this study, we investigated whether polymorphisms in IL-1α contribute to human obesity. A total of 260 obese subjects were genotyped for IL-1α C-889T (rs1800587) and ...

AIM The α1-antitrypsin-low-density lipoprotein complex (AT-LDL) and serum amyloid A-LDL complex (SAA-LDL) are oxidatively modified LDL complexes that promote atherosclerosis. The serum levels of AT-LDL and SAA-LDL are suggested to be increased by obesity and smoking. We have previously demonstrated that larger weight gain after smoking cessation (SC) perturbs a decrease in the serum level of AT...

To reduce weight gain and encourage healthy eating including reduced sugar intake, Under 5 Energize (U5E) was introduced to 121 early-childhood-centres in the Waikato region of New Zealand in July 2013. Using anonymized data collected from January 2013 to September 2016 through free physical assessments of all 4-year-olds provided by the NZ Ministry of Health, the prevalence of obesity and dent...

The cg07814318 hypermethylation of Kruppel-like factor 13 (KLF13) gene has been reported for its relevancy with Body Mass Index (BMI) from European origin. We explored the cg07814318 methylation and its cis-meQTL (cis-methylation quantitative loci) of KLF13 from a childhood obesity cohort. The cg07814318 methylation in blood was significantly associated with obesity and correlated with several ...