CC-122 hydrochloride is a novel pleiotropic pathway modifier compound that binds cereblon, a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex. CC-122 has multiple activities including modulation of immune cells, antiproliferative activity of multiple myeloma and lymphoma cells, and antiangiogenic activity. CC-122 is being developed as an oncology treatment for hematologic mal...

Future of Avian Genetic Resources Collections: Archives of Evolutionary and Environmental History.—In the past 30 years, genetic resources collections (GRCs) have shiĞ ed position within ornithology, from a novel supplement to traditional voucher collections to a major core source of raw material fueling multiple subdisciplines. The demand for specimens from GRCs now greatly exceeds both the de...

This article reports the yield estimation of vineyards from using a mobile millimeter-wave radar system. The proximal sensor is 122-GHz FM-CW mounted on rover that moves along furrows between vine plants. proposed based classification echoes measured for various grape varieties, different meteorological conditions, and at stages development. As errors are found to be lower than 10%, technique s...

Alkaline-earth iron arsenide (122) is one of the most studied families iron-based superconductors, especially for angle-resolved photoemission spectroscopy. While extensive results have been obtained, surface complexity 122 caused by its charge-non-neutral rarely considered. Here, we show that can be neutralized potassium deposition. In potassium-coated BaFe$_2$(As$_{0.7}$P$_{0.3}$)$_2$, surfac...

The present study aims to explore the possible mechanisms underlying the multidrug resistance characteristic of Cryptosporidium parvum by detecting the presence of ATP-binding cassette (ABC) protein encoding genes, especially one that shows high similarity to members belonging to the multidrug resistance protein (MDR) and multidrug resistance associated protein (MRP) subfamilies. PCR using ABC-...

Multiple sclerosis (MS) is an inflammatory and autoimmune disease.MS is characterized by blood brain barrier breakdown, inflammation, axonal injury, degeneration of the myelin sheath and etc. A significant association between inflammation and degeneration of neurons is observed in the brain. Also active MS lesions always associated with inflammation thus inflammation is a target for treatment o...

while weeds in sugar beet farming reduce crop yield and quality, they also lead to higher labor and material losses. in recent years, in order to eliminate or reduce the damage caused by weeds in sugar beet farming, weed control has gained importance. to this end, various studies have been conducted on robotic weed control by detecting weeds using image processing algorithms and hoeing or spray...

The structure determination of canine parvovirus depended on the extension of phases calculated initially from a spherical-shell model [Tsao, Chapman, Wu, Agbandje, Keller & Rossmann (1992). Acta Cryst. B48, 75-88]. Such ab initio phasing holds the promise of obviating initial experimental phasing by isomorphous or molecular replacement, thereby expediting the structure determinations of spheri...