Preconditioning stimulus: Preconditioning is an adaptive response, whereby a small dose of a harmful substance protects the brain from a subsequent damaging insult (Dirnagl et al., 2009). The concept of preconditioning was first described in an ischemic heart model, it was observed that brief ischemic episodes protect against a subsequent ischemic insult (Murry et al., 1986). Consequently, seve...

BACKGROUND Anesthetic and ischemic preconditioning share similar signal transduction pathways. The authors tested the hypothesis that the beta1-adrenergic signal transduction pathway mediates anesthetic and ischemic preconditioning in vivo. METHODS Pentobarbital-anesthetized (30 mg/kg) rabbits (n = 96) were instrumented for measurement of systemic hemodynamics and subjected to 30 min of coron...

Ischemic preconditioning is a well-established phenomenon first described in experimental preparations in which brief episodes of ischemia/reperfusion applied prior to a longer coronary artery occlusion reduce myocardial infarct size. There are ample correlates of ischemic preconditioning in the clinical realm. Preconditioning mimetic agents that stimulate the biochemical pathways of ischemic p...

BACKGROUND Activation of protein kinase C epsilon (PKC-epsilon) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) are important for cardioprotection by preconditioning. The present study investigated the time dependency of PKC-epsilon and ERK1/2 activation during desflurane-induced preconditioning in the rat heart. METHODS Anesthetized rats were subjected to regional myocardial ische...

In this paper, we consider the numerical solution of poroelasticity problem with stochastic properties. We present a Two-stage Markov Chain Monte Carlo method for geomechanical subsidence. work, study two techniques preconditioning: (MS) multiscale model order reduction and (ML) machine learning technique. The purpose preconditioning is fast sampling, where new proposal first tested by cheap so...

background: the aim of this study was to investigate the effects of high-intensity interval training (hiit) on nitric oxide metabolites (no2 - , no3 - ) and myocardial infarct size after ischemia/reperfusion (i/r) injury in healthy male rats. methods: a total of 44 wistar rats were randomly divided into 4 groups including hiit (n=8), hiit + ir protocol (n=14), control (n=8), and control + ir (n...

objective: ischemic preconditioning (ipc) is an endogenous phenomenon that can induce ischemic tolerance (it) in variety of organs such as brain. in this study, we examined the intermittent and prolonged normobaric hyperoxia (ho) on neurologic deficit scores, infarct volume, and superoxide dismutase activity. materials and methods: the rats were divided to four main groups. first two main grou...

Cardiac preconditioning is the most potent and consistently reproducible method of protecting heart tissue against myocardial ischemia-reperfusion injury. This review discussed about the signaling and amplification cascades from either ischemic preconditioning stimulus or pharmacological preconditioning stimulus, the putative end-effectors and the mechanisms involved in cellular protection. The...

There is compelling evidence that preconditioning occurs in humans. Experimental studies with potential clinical implications as well as clinical studies evaluating ischaemic, pharmacological and anaesthetic cardiac preconditioning in the perioperative setting are reviewed. These studies reveal promising results. However, there are conflicting reports on the efficacy of preconditioning in the d...