Prednisolone is a synthetic corticosteroid acting on both hydrosaline balance and metabolism that is liable to fraudulent administration to meat-producing animals for growth-promoting purposes. Its use outside strict therapeutic control and prescription is banned by the European legislation, but official controls are hampered by its negligible direct excretion into the urinary matrix. Recent st...

BACKGROUND Previous meta-analyses of treatments for Bell's palsy are still inconclusive due to different comparators, insufficient data, and lack of power. We therefore conducted a network meta-analysis combining direct and indirect comparisons for assessing efficacy of steroids and antiviral treatment (AVT) at 3 and 6 months. METHODS We searched Medline and EMBASE until September 2010 using ...

The etiology of vitamin B(6) depletion in inflammation remains unknown. Hepatic vitamin B(6) decreased in adrenalectomized rats, and such reductions were restored by an acute muscle injection of a very high dose of glucocorticoids. We tested the hypothesis that long-term prednisolone treatment for treating inflammation restores vitamin B(6) status by induction of tissue B6 metabolic enzymes. Tw...

Huybers S, Naber TH, Bindels RJ, Hoenderop JG. Prednisolone-induced Ca malabsorption is caused by diminished expression of the epithelial Ca channel TRPV6. Am J Physiol Gastrointest Liver Physiol 292: G92–G97, 2007. First published August 10, 2006; doi:10.1152/ajpgi.00317.2006.—Glucocorticoids, such as prednisolone, are often used in clinic because of their anti-inflammatory and immunosuppressi...

The survival of asynchronously growing lymphoid cells (T, cells) in vitro decreased to 50% viability after 1 hr treatment with concentrations of prednisolone above 10 ftg/ml. Treatment with prednisolone for 24 hr produced a decrease in cell survival to a plateau of 30% viability for concentrations above 10 ig/ml. After 48 hr treatment, 10 ig/ml prednisolone reduced viability to 12%. Synchronous...

The effect of prednisolone on the elimination kinetics of theophylline was studied in a group of nine patients with chronic airflow obstruction. Volume of distribution, plasma half life, and clearance after a single intravenous dose of aminophylline (5.6 mg/kg) were unchanged by prednisolone treatment (20 mg daily for three weeks). The metabolism of an intravenous bolus of theophylline is not i...

In a prospective study of 74 patients and a retrospective study of 35 patients with polymyalgia rheumatica/giant cell arteritis steroid related side effects occurred in at least one third of patients, and in two thirds if weight gain was included. Side effects were significantly related to an initial prednisolone dose of more than 30 mg and to the cumulative prednisolone dose. Patients taking a...

We describe a case of recurrent invasive thymoma associated with myasthenia gravis that responded to combined treatment with prednisolone and tacrolimus. The patient suffered from a myasthenic crisis and received methylprednisolone pulse therapy and partial thymomectomy. Low maintenance doses of prednisolone and tacrolimus shrank the size of the invasive thymoma and maintained the patient witho...

OBJECTIVE To determine whether ciclosporin is superior to prednisolone for the treatment of pyoderma gangrenosum, a painful, ulcerating skin disease with a poor evidence base for management. DESIGN Multicentre, parallel group, observer blind, randomised controlled trial. SETTING 39 UK hospitals, recruiting from June 2009 to November 2012. PARTICIPANTS 121 patients (73 women, mean age 54 y...

OBJECTIVE Bell's palsy is a rapid onset, usually, unilateral paralysis of the facial nerve that causes significant changes in an individual's life such as a decline in personal, social, and educational performance. This study compared efficacy of combined prednisolone and acyclovir therapy with prednisolone alone. MATERIALS & METHODS This study is a randomized controlled trial conducted on 43...