Introduction: Evaluation of the cerebrospinal fluid (CSF) white blood cell (WBC) count and glucose and protein concentrations is used to assess the probability of the presence of central nervous system (CNS) infection. Although normal values are well established for CSF cell counts and protein and glucose contents in children and adults, this is not the case for neonates. The purpose of this st...

Background:  A great number of premature neonates do not tolerate sufficient milk during the early neonatal period. Objective: To evaluate the effect of oral erythromycin on enhancement of feeding tolerance in preterm newborns. Methods: Sixty preterm neonates intolerant to milk of >75 ml/kg/day during 5 days after the start of feedings, were randomized into a treatment and a control groups.  Or...

background: the newborn’s first bath, performed in neonatal intensive care units (nicu), is believed to be a stressful situation, especially for the premature infants. as a developmental care approach, swaddle bathing is a low-stress bathing method for vulnerable preterm neonates. given the limited number of the studies examining this bathing method, the present study was conducted with the aim...

Objective: Preterm infants are prone to intraventricular hemorrhage. They may suffer from significant morbidity and mortality particularly in those with high-grade hemorrhage. Our objective was to determine the incidence of intraventricular hemorrhage in premature infants transported to a tertiary center compared with those delivered at the level III facility.  Methods: We evaluated all prematu...

BACKGROUND AND PURPOSE The accurate identification of white matter injury in premature neonates is important for counseling parents and for targeting these high risk neonates for appropriate rehabilitation services. The objective of this study was to compare the diagnosis of white matter injury detected by serial MR imaging and ultrasonography of a contemporary cohort of premature neonates. M...

Background. Inhaled nitric oxide improves oxygenation and lessens the need for extracorporealmembrane oxygenation in full-term neonates with hypoxaemic respiratory failure and persistent pulmonary hypertension, but potential adverse effects are intracranial haemorrhage and chronic lung disease. We investigated whether low-dose inhaled nitric oxide would improve survival in premature neonates wi...

BACKGROUND A few studies have been carried on preventive drugs for apnea of preterm neonates. OBJECTIVES This study aimed to assess the safety and prophylactic effects of aminophylline on the incidence of apnea in premature neonates. PATIENTS AND METHODS This study was a randomized clinical trial (RCT) research. The prophylactic effect of aminophylline on apnea was investigated in premature...

Caffeine is widely used for the treatment of apnea in premature neonates. However, the localization of caffeine's target site (central nervous system and/or peripheral chemoreceptors) is not well defined, especially for sleeping neonates whose sleep stages interact with respiratory control. The aim of this study was to assess the activity of the peripheral chemoreceptors in relation to sleep st...