Isatin, N-methyl isatin and N-benzylisatin were smoothly monobrominated in the 5-position by treatment with pyridinium bromochromate (PBC) in acetic acid medium. In the similar conditions indigo underwent bromination and oxidation to give 5-bromoisatin in high yield.

      The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained re...

In this paper we present a method for preparation of technical drawings in the domain of electroplating lines. We treat the method as the combination of two tasks: configuration and document preparation. The proposed method combines the basic concepts of these domains: generic coding introduced in document preparation task and component oriented approach used in the configuration task. We show ...