A solution is developed for the build-up, steady and post-arrest dissipative pore fluid pressure fields that develop around a blunt penetrometer that self-embeds from freefall into the seabed. Arrest from freefall considers deceleration under undrained conditions in a purely cohesive soil, with constant shear strength with depth. The resulting decelerating velocity field is controlled by soil s...

Mollisols of Santa Fe have different tilth and load support capacity. Despite the importance of these attributes to achieve a sustainable crop production, few information is available. The objectives of this study are i) to assess soil physical indicators related to plant growth and to soil mechanical behavior; and ii) to establish relationships to estimate the impact of soil loading on the soi...

We report a biolistic technology platform for physical delivery of particle formulations of drugs or vaccines using parallel arrays of microchannels, which generate highly collimated jets of particles with high spatial resolution. Our approach allows for effective delivery of therapeutics sequentially or concurrently (in mixture) at a specified target location or treatment area. We show this ne...

Insertion profiles of antitubercular drugs isoniazid (INH), rifampicin (RFM) and ethambutol (ETH) into dipalmitoylphosphatidylcholine (DPPC) membrane models were evaluated by Langmuir monolayer technique. Maximum drug insertion into DPPC monolayer was observed with rifampicin with a surface pressure increase (Deltapi(max)) in the range of 21-33 mN/m depending upon rifampicin concentration. Ison...

Flessner, Michael F., Jaehwa Choi, Zhi He, and Kimberly Credit. Physiological characterization of human ovarian cancer cells in a rat model of intraperitoneal antineoplastic therapy. J Appl Physiol 97: 1518 –1526, 2004. First published June 4, 2004; 10.1152/ japplphysiol.00305.2004.—Destruction of cancer cells by therapies directed against new molecular targets requires their effective delivery...

BACKGROUND It is recognized that, as a result of variation in tissue anatomy, current auto-injectors may have insufficient needle length to achieve successful intramuscular agent delivery in a number of patients. The Zeneo® auto-injector is a novel prefilled, single-use, needle-free device currently in development for intradermal, subcutaneous, and intramuscular agent delivery across a variety ...

A solution is developed for the buildup, steady, and postarrest dissipative pore fluid pressure fields that develop around a conical penetrometer that self-embeds from free-fall into the seabed. Arrest from free-fall considers deceleration under undrained conditions in a purely cohesive soil, with constant shear strength with depth. The resulting decelerating velocity field is controlled by soi...

Destruction of cancer cells by therapies directed against new molecular targets requires their effective delivery to the tumor. To study diffusion and convection of intraperitoneal (ip) therapy to ip tumors, we established a new athymic rat (RNU) model with ovarian tumor cells (SKOV3 and OVCAR3) implanted in the abdominal wall. The model simulates metastatic tumor and facilitates the measuremen...

This paper investigates the effect of micropile installation into saturated sandy soil by means of finite element method. The obtained results from numerical modeling are compared with the received data from the site. The validation of software has been done by simulating standard penetration test. The effect of some changes in spacing (3m, 1.6m and 0.8m) and injection pressure (1cm, 2.5cm, 5cm...