Chorioamnionitis is frequently associated with preterm birth and increases the risk of adverse outcomes such as bronchopulmonary dysplasia (BPD). Transforming growth factor (TGF)-beta1 is a key regulator of lung development, airway remodeling, lung fibrosis, and regulation of inflammation, and all these processes contribute to the development of BPD. Connective tissue growth factor (CTGF) is a ...

background: pregnancy is associated with unfavorable metabolic profile, which might in turn result in adverse pregnancy outcomes. the current study was designed to evaluate the effects of calcium plus vitamin d administration on metabolic status and pregnancy outcomes in healthy pregnant women. methods: this randomized double‑blind placebo‑controlled clinical trial was performed among 42 pregna...

background: considering the existence of controversies about the predictive value of inflammatory markers for cardiovascular disease (cvd), we aimed to compare the level of high?sensitivity c?reactive protein (hs?crp) and interlukin?6 (il?6) level in chronic hemodialysis (hd) patients with and without cvd. materials and methods: in this historical cohort study, hd patients with and without cvd ...

BACKGROUND AND OBJECTIVE Preeclampsia is a systemic disorder, affecting 2-10% of pregnancies, characterized by a deregulated pro- and anti-angiogenic balance. Semaphorin 3F is an angiogenesis inhibitor. We aimed to investigate whether semaphorin 3F expression is modulated in preeclampsia. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS We performed two observational single center cohort studi...

Purpose: The proper function of amnion is necessary for a normal pregnancy and delivery to occur. Understanding the change of amnion between term and preterm labor leads to a better method of diagnosis and prevention for preterm labor. Lysyl oxidase (LOX) catalyzes a series of reactions about the formation of cross-linking of collagen fibrils. Human amniotic tissue, containing a large amount of...