The Bacille Calmette-Guérin (BCG) is live and attenuated strain of Mycobacterium bovis which is used throughout the world as vaccine against tuberculosis. BCG vaccination contributes to the prevention and control of tuberculosis in limited situations when other strategies are inadequate. As there is currently no alternative, BCG will continue to be used in future as vaccine and also as a prime ...

Results of the RV144 study of a primeboost regimen combining a canarypox vector-based candidate ALVAC-HIV (vCP1521) and AIDSVAX B/E gp120 human immunodeficiency virus (HIV) envelope showed a modest but statistically significant 31% reduction in the rate of HIV infection in healthy volunteers (Rerks-Ngarm et al, 2009). These promising results need to be confirmed in further clinical trials and r...

Purpose: The goal of this study was to test the safety and activity of a therapeutic vaccine, MKC1106-MT, in patients with metastatic melanoma. Experimental Design: MKC1106-MT comprises a plasmid (pMEL-TYR) and two peptides (E-MEL and E-TYR), corresponding to Melan A and tyrosinase, administered by intra–lymph node injection in a primeboost sequence. All 18 patients were HLA-A*0201 positive and...

Heterologous prime-boost immunizations with plasmid DNA and viral vaccines synergize to produce effective immune responses against tumor and infectious disease antigens. Yet, mechanisms underlying their synergy remain incompletely defined. Here, we used the colorectal cancer (CRC) antigen guanylyl cyclase C (GUCY2C) to explore the synergy of DNA-Ad5 (adenovirus type 5) prime-boost immunizations...

Development of a TB vaccine for cattle is a research priority in Great Britain. Two challenges need to be addressed. Firstly, vaccine strategies enhancing the efficacy of M. bovis bacille Calmette Guérin (BCG), currently the only potentially available TB vaccine, and secondly the development of a diagnostic test to be used alongside vaccination to differentiate vaccinated and infected animals (...