Genetic factors play a major role in the etiology of many human diseases. Genome-wide experimental methods produce an increasing number of genes associated with such diseases. This chapter introduces data sources, bioinformatics tools, and computational methods for prioritizing disease candidate genes and identifying disease pathways. The main strategy is to examine the similarity among the can...

MacroBase is a new kind of data analysis engine designed to prioritize human attention in large-scale fast data streams. Given increasing data volumes that are increasingly too large for manual inspection, MacroBase highlights interesting behaviors in streams and produces explanations for these behaviors that can be used for tasks including diagnostics, alerting, and root cause analysis. MacroB...

In nature reserves and habitat conservation areas, monitoring is required to determine if reserves are meeting their goals for preserving species, ecological communities, and ecosystems. Increasingly, reserves are established to protect multiple species and communities, each with their own conservation goals and objectives. As resources are always inadequate to monitor all components, criteria ...

4 Example: Breast cancer 3 4.1 Data sets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4.2 Assembling the data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 4.3 Applying the model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 4.4 Plotting and tabulating the P-values . . . . . . . . . . . . . . . . . . . . ...

Hospital pharmacy practice has undergone many changes over the past 3 decades. New technologies, such as automated repackaging, robotic unit-dose cart-fill systems, and automated dispensing cabinets, have improved the efficiency, effectiveness, and quality of drug distribution systems. In addition, new pharmacy practice models have been introduced in which pharmacists accept responsibility and ...

Multi-agent systems offer capabilities that single agent systems cannot. Chief among these capabilities are robustness, scalability, modularity, and the ability to distribute the agents throughout their environment. Along with these capabilities, however, comes the challenge of coordination the agents so they are able to achieve their goals effectively and efficiently. Our work focuses on the i...

I t i s m id -afternoon in december in a community meeting room in Wolverhampton, a small city in England’s Midlands. It is damp and the wind is up, and it is nice to learn that afternoon tea will be served prior to conducting business. Daphne Austin, a public health physician from a local service agency, sets about serving tea and biscuits to nine people who have been recruited to discuss thei...

D eveloping software in 2016 is different than it was when IEEE Security & Privacy magazine was founded in 2003. Developers now need to know about the constantly evolving threat landscape, the challenging complexity of systems security, and the accelerating pace of software and system development. Computer attacks in 2003 were rare enough that the term computer worms had to be defined when repo...

BACKGROUND To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands. METHODOLOGY/PRINCIPAL FINDINGS A risk score was based on seven criteria, reflecting assessments of the epidemiology and impact of these pathogens on so...

One of the daily tasks of an enterprise architect is to prioritize strategic IT projects. To achieve a business-IT alignment, this prioritization needs to be based on business strategies and goals. Therefore, business goals and their traceability to strategic IT projects are relevant for the enterprise architect. However, surprisingly little formalisations and reasoning techniques have been dev...