BACKGROUND Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, has a pro-apoptotic effect on colon adenocarcinoma cells via COX-independent mechanisms. MATERIALS AND METHODS The pro-apoptotic effect of N-(2-Aminoethyl)-4-[5- (4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide (TT101), a new derivative of celecoxib, was investigated on the HT-29 and SW480 colon adenocarcinom...

The proto-oncoprotein c-Cbl controls several down-regulation signals leading to degradation of tyrosine-kinase receptors (TKR) [1-3] or endocytic trafficking [1,4,5]. It interacts with numerous signalling proteins through their Src homology-2 or -3 (SH2 or SH3) domains [6,7]. Several groups, including ours, have reported an association between down-regulation of apoptosis and c-Cbl. First, onco...

Aims: Cyclophosphamide (CP) is a broad-spectrum chemotherapy agent available to treat various malignancies; however, its nephrotoxicity limits clinical use. Formononetin (FOR) bioactive isoflavone with encouraging biological activities. The current study explored and elucidated the possible protective/therapeutic effects of formononetin against CP-induced nephrotoxicity.
 Methodology: Rats...

We aimed to investigate the potential anticonvulsant effect of green synthetized selenium nanoparticles (SeNPs) using Syzygium aromaticum extract (SAE) (SAE-SeNPs) against epileptic seizures and cortical damage induced by pentylenetetrazole (PTZ) injection in rats its mechanism. A total 84 were divided into six groups; control, PTZ-exposed group, SAE + PTZ-treated sodium selenite (Na2SeO3) SAE-...

The intrinsic pathway of apoptosis is regulated by the Bcl-2 family proteins. Inhibition anti-apoptotic members represents a strategy to induce apoptotic cell death in cancer cells. We have measured membrane binding properties series peptides, including modified α/β-peptides, designed exhibit enhanced permeability allow entry and improved access for engagement members. peptide cargo based on pr...

Background: Due to high mortality of patients with metastatic breast cancer and limited strategies for management this malignancy, development novel therapeutic approaches anti-cancer agents is essential. Objectives: In the present study, we investigated in vitro anti-proliferative effects hydroxytyrosol, as a natural chemotherapeutic agent, against cells MDA-MB-231 MCF-7. Methods: The anti-pro...

Sponges of the porifera family harbor some of the evolutionary most ancient orthologs of the B-cell lymphoma-2 (Bcl-2) family, a protein family critical to regulation of apoptosis. The genome of the sponge Geodia cydonium contains the putative pro-survival Bcl-2 homolog BHP2, which protects sponge tissue as well as mammalian Hek-293 and NIH-3T3 cells against diverse apoptotic stimuli. The Lake ...

Excessive apoptosis of intervertebral disk cells and degeneration (IDD) is the prime cause low back pain. B-cell lymphoma 2 (Bcl-2) adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member Bcl-2 family, are involved in cell autophagy apoptosis. The roles mechanisms BNIP3 unclear. In this study, primary rat were prepared to study effect overexpression on their counting kit (CCK)-8 assay sho...

Abstract FK506-binding protein 2 (FKBP13) is a part of the immunophilin family involved in immunoregulation. It also believed to operate as factor membrane cytoskeletal framework and an ER chaperone. FKBP2 FKBP1 (FKBP12), known immunophilins, are binding proteins for rapamycin FK506, which immunosuppressive drugs. was suggested that immunophilin-like play significant roles regulating intracellu...