This study evaluated the effects of Mesobuthus eupeus (Me) scorpion venom on inflammatory response following injection. Additionally, the present study examined whether immunotherapy at specific time intervals would be effective on inflammatory response after Me venom inoculation. Animals were divided randomly into four groups: the first group received LD50 of venom and the second and third gro...

introduction: knee osteoarthrosis is one of the most debilitating diseases. prolotherapy includes intraarticular injection of various drugs to decrease inflammation. injection of intradiscal o2-o3 has reduced pain and disability of patients with low back pain due to prolapsed lumbar disk. objective: to compare the effect of intraarticular injection of ozone and steroids in improvement of clinic...

UNLABELLED Rheumatoid arthritis (RA) is a chronically inflammatory disease of the articular synovial, with severe, progressive and irreversible articular destruction. RA pathogeny implies an autoimmune mechanism, the role of cytokines resulting from the exaggerated production of some cytokines that act as pro-inflammatory agents, being directly responsible of certain symptoms and articular dest...

THE AIM OF THE STUDY The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis. MATERIAL AND METHODS The study included 160 women, who were divided in two study groups (Group I - endometriosis; Group 2 - healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α...

Acute psychosocial stress stimulates transient increases in circulating pro-inflammatory plasma cytokines, but little is known about stress effects on anti-inflammatory cytokines or underlying mechanisms. We investigated the stress kinetics and interrelations of pro- and anti-inflammatory measures on the transcriptional and protein level. Forty-five healthy men were randomly assigned to either ...

The objective of this paper was to study the changes of some cytokines and neuroendocrine hormones in vaccinated and unvaccinated pigs that were naturally infected by a PRRSV-1 (porcine reproductive and respiratory syndrome virus) heterologous field strain. We analyzed gene expression of pro-inflammatory (TNF-α, IL-1β, MCP-1, IL-6), pro-immune (IFN-γ) and anti-inflammatory cytokines (IL-10) in ...

Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesicagent, but no systematic study of its effects on several markers associated with rheumatoidarthritis and its ethnomedical use as analgesic agent has been performed. We evaluated theanti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) barkand its rich-flavonoids frac...

Human macrophages are reprogrammed by graphdiyne oxide from M2 to M1 macrophages, leading degradation of GDYO through a peroxynitrite-driven pathway with subsequent modulation pro-inflammatory cytokines including IL-1?.

Stroke causes neuronal necrosis and generates inflammation. Pro-inflammatory molecules intervene in this process by triggering glial cell activation and leucocyte infiltration to the injured tissue. Cytokines are major mediators of the inflammatory response. Pro-inflammatory and anti-inflammatory cytokines are released in the ischaemic brain. Anti-inflammatory cytokines, such as interleukin-10,...

BACKGROUND Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved. METHODS The effects of an ethanol extract of SM (ESM) on pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and NO, on anti-inflammatory cytokines including IL-4, IL-10, TGF-β, and IL-1Ra have been studied...