Bregs: B regulatory cells BP: bullous pemphigoid CTLA-4: cytotoxic T-lymphocyteeassociated protein 4 IRAE: immune-related adverse events PD-1: programmed cell death protein 1 PD-L1: programmed death ligand

Pembrolizumabas yra programuotos ląstelės žūties baltymo-1 (angl. anti-programmed cell death protein-1, PD-1) inhibitorius, patvirtintas metastazavusio nesmulkiųjų ląstelių plaučių vėžiui (NSLPV) gydyti tiek monoterapijai, kuomet navikiniame audinyje nustatyta didelė baltymo ligando-1 protein ligand-1, PD-L1) raiška, skiriant kartu su chemoterapija, nepriklausomai nuo PD-L1 raiškos audinyje. II...

Although immune checkpoint inhibitors (ICIs) have provided a welcome paradigm shift in treating NSCLC with remarkable survival benefits some patients, their success has been tempered by low response rates and difficulty identifying accurate predictive biomarkers. Effective biomarkers to help identify responders, minimize unnecessary cost toxicity nonresponders, when use different combination tr...