Similar to other parts of the central nervous system, there are two types of programmed cell death during retinal development. In early development, the neuronal progenitor population is affected. In the mouse eye, this kind of programmed cell death begins at around embryonic day (E) 12.5 and peaks between E14.5 and E16.5. The second phase of programmed cell death occurs during synaptogenesis w...

Programmed death receptor 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) are immune checkpoint inhibitors that effectively esteemed destinations of immunotherapies for the management melanoma several cancers. The monotherapy included monoclonal antibodies approved such as Ipilimumab, Pembrolizumab, Nivolumab planned to restrict with T-cell inhibitory signals activate response...

Therapeutic strategies targeting the programmed cell death-ligand 1/programmed cell death-1 pathway have shown significant responses and good tolerability in solid malignancies. Although preclinical studies suggest that inhibiting programmed cell death-ligand 1/programmed cell death-1 interactions might also be highly effective in hematological malignancies, remarkably few clinical trials have ...

FDG: fluorodeoxyglucose LPP: lichen planopilaris PET-CT: positron emission tomographye computed tomography PD-1: programmed cell death receptor 1 P embrolizumab, a programmed cell death receptor 1 (PD-1) inhibitor, has been used effectively for treatment of metastatic melanoma. Reported cutaneous adverse events ascribed to PD-1 inhibitors include lichenoid reactions such as lichen planus of the...