Introduction: Given to the fact that the high toxicity and side effects of chemotherapeutic drugs have limited their clinical use, it is not surprising that novel therapeutic drugs with less toxicity and more efficacy have entered into the novel protocols. Relatively, Melatonin, a main product of pineal gland, not only plays a key role in the regulation of circadian rhythm, but also exerts anti...

Background: Isosorbide dinitrate has been broadly used in the treatment of various ischemic heart diseases. Isosorbide is a nitric oxide donor which increases blood flow to tumors through vasodilatation and consequently accelerates the access of chemo-drugs to them. Furthermore, this drug has inhibitory effects on angiogenesis, tumor growth and metastasis in vivo. Moreover, its ant-inflammatory...

Purpose: Nicotine can induce sub fertility or infertility both in males and females. The aim of this study is to evaluate the proliferative activity of adult mouse male germ cells following treatment with different doses of nicotine.Materials and Methods: Adult male NMRI mice were divided into four groups. The control group received normal saline and the other animals in groups of 2, 3 and 4 we...